Vitamin D-Binding Protein in Healthy Pre- and Postmenopausal Women: Relationship with Estradiol Concentrations
| Autor: | Xiangbing Wang, Brian Chang, Wei Sun, L. Claudia Pop, Sue A. Shapses |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Vitamin medicine.medical_specialty genetic structures Vitamin D-binding protein Endocrinology Diabetes and Metabolism Serum estradiol Endogeny Article chemistry.chemical_compound Endocrinology Internal medicine medicine Vitamin D and neurology Humans Vitamin D Postmenopausal women Estradiol Extramural business.industry Vitamin D-Binding Protein General Medicine Middle Aged Postmenopause Premenopause chemistry Female business circulatory and respiratory physiology |
| Zdroj: | Endocrine Practice. 21:936-942 |
| ISSN: | 1530-891X |
| Popis: | To examine the relationship between endogenous serum estradiol and vitamin D-binding protein (DBP) and total, free, and bioavailable 25-hydroxyvitamin D (25OHD) concentrations in pre- and postmenopausal women.In 165 healthy women (ages, 26 to 75 years) not taking any form of exogenous estrogen, the serum concentrations of estradiol, 25OHD, DBP, parathyroid hormone, and albumin were measured. Free and bioavailable 25OHD (free + albumin-bound) levels were calculated from total 25OHD, DBP, and serum albumin levels.Premenopausal women had higher serum 25OHD (31.5 ± 7.9 ng/mL), DBP (45.3 ± 6.2 mg/dL), and estradiol (52.8 ± 35.0 pg/mL) levels than postmenopausal women (26.5 ± 4.9 ng/mL, 41.7 ± 5.7 mg/dL, and 12.9 ± 4.9 pg/mL), respectively. In addition, the calculated free and bioavailable 25OHD levels were higher in pre- than postmenopausal women (P.05). Serum estradiol correlated with DBP (r = 0.22; P.01) and total 25OHD (r = 0.27; P.01). In multivariate regression models (with or without serum 25OHD), estradiol was independently associated with DBP (P.05).Lower estradiol level is one of the factors that contribute to lower DBP levels in older women. Our data indicate that besides well-known factors such as age, gender, and race, serum estradiol concentrations are also a physiologic predictor of DBP concentration. |
| Databáze: | OpenAIRE |
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