Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population
| Autor: | Selvin Edwards, G. Russell Warnick, Elizabeth T. Leary, William J. Korzun, W. Greg Miller, Hendrick E. van Deventer, Robert D. Shamburek, Andrzej Dziekonski, Ikunosuke Sakurabayashi, Lorin M. Bachmann, Masakazu Nakamura, Katsuyuki Nakajima, George W. Vetrovec, Samuel P. Caudill, Alan T. Remaley, Mary M. Kimberly, Gary L. Myers |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Concordance Clinical Biochemistry Population Gastroenterology Risk Assessment Sensitivity and Specificity Article chemistry.chemical_compound Risk Factors Internal medicine medicine Humans Risk factor education Triglycerides Dyslipidemias education.field_of_study Framingham Risk Score Triglyceride business.industry Cholesterol Biochemistry (medical) Cholesterol HDL Case-control study Reproducibility of Results Cholesterol LDL Fasting Endocrinology chemistry Cardiovascular Diseases Case-Control Studies Data Interpretation Statistical Risk assessment business Ultracentrifugation Blood Chemical Analysis |
| Zdroj: | Clinical chemistry. 57(3) |
| ISSN: | 1530-8561 |
| Popis: | BACKGROUNDOur objective was to evaluate the accuracy of cardiovascular disease (CVD) risk score classification by direct LDL cholesterol (dLDL-C), calculated LDL cholesterol (cLDL-C), and non–HDL cholesterol (non–HDL-C) compared to classification by reference measurement procedures (RMPs) performed at the CDC.METHODSWe examined 175 individuals, including 138 with CVD or conditions that may affect LDL-C measurement. dLDL-C measurements were performed using Denka, Kyowa, Sekisui, Serotec, Sysmex, UMA, and Wako reagents. cLDL-C was calculated by the Friedewald equation, using each manufacturer's direct HDL-C assay measurements, and total cholesterol and triglyceride measurements by Roche and Siemens (Advia) assays, respectively.RESULTSFor participants with triglycerides CONCLUSIONSExcept for hypertriglyceridemic individuals, 7 of 8 dLDL-C methods failed to show improved CVD risk score classification over the corresponding cLDL-C methods. Non–HDL-C showed overall the best concordance with the RMP for CVD risk score classification of both normal and hypertriglyceridemic individuals. |
| Databáze: | OpenAIRE |
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