A certain proportion of docosahexaenoic acid tends to revert structural and dynamical effects of cholesterol on lipid membranes
| Autor: | Gustavo A. Appignanesi, L. M. Alarcón, A.R. Verde, Marcela A. Morini, Viviana Isabel Pedroni, María Belén Sierra |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Docosahexaenoic Acids Molecular Structure Chemistry Cholesterol Lipid Bilayers Temperature technology industry and agriculture Biophysics Cell Biology Biochemistry chemistry.chemical_compound Molecular dynamics Membrane Ultrasonic Waves Docosahexaenoic acid Dipalmitoylphosphatidylcholine Liposomes Phosphatidylcholines Zeta potential lipids (amino acids peptides and proteins) Lipid bilayer Polyunsaturated fatty acid |
| Zdroj: | Biochimica et Biophysica Acta (BBA)-Biomembranes |
| ISSN: | 0005-2736 |
| Popis: | This work investigates how docosahexaenoic acid (DHA) modifies the effect of Cholesterol (Chol) on the structural and dynamical properties of dipalmitoylphosphatidylcholine (DPPC) membrane. We employ low-cost and non-invasive methods: zeta potential (ZP), conductivity, density, and ultrasound velocity, complemented by molecular dynamics simulations. Our studies reveal that 30% of DHA added to the DPPC-Chol system tends to revert Chol action on a model lipid bilayer. Results obtained in this work shed light on the effect of polyunsaturated fatty acids - particularly DHA - on lipid membranes, with potential preventive applications in many diseases, e.g. neuronal as, Alzheimer's disease, and viral, as Covid-19. |
| Databáze: | OpenAIRE |
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