Prolongation of rat heart allograft survival by a synthetic progestogen (melengestrol acetate) and ara-cytidine acylates
| Autor: | Akiyoshi Sakai, Pettirossi O, Kountz Sl, Wechter Wj |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Time Factors medicine.medical_treatment Benzoates Melengestrol acetate Pyrimidine analogue chemistry.chemical_compound Internal medicine Pregnadienes Rats Inbred BN Allograft survival medicine Animals Transplantation Homologous Rats Inbred BUF Melengestrol Acetate Heart transplantation Transplantation Progestogen Cytarabine Cytidine Rat heart Rats Rats Inbred ACI Endocrinology chemistry Rats Inbred Lew Heart Transplantation Caprylates medicine.drug |
| Zdroj: | Transplantation. 21(5) |
| ISSN: | 0041-1337 |
| Popis: | Immunosuppressive effects of newly developed synthetic progestins, melengestrol acetate (MGA), and three pyrimidine analogs, ara-cytidine (Ara-C), Ara-C 5'-benzoate and octanoate, were investigated on the heart allograft survival in the rat. MGA at the dose of 25 mg/kg given every 3rd day starting 1 day before the grafting through day 20 prolonged the graft survival significantly without toxic effects (80.2 +/- 40.2 days versus control 7.0 +/- 0.1 days). The high dose (50 mg/kg/day) was more effective (137.4 +/- 26.6 days) but a high incidence of multiple abscesses (37%) was also noted. The other three agents were either highly toxic or not immunosuppressive. |
| Databáze: | OpenAIRE |
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