Fetal umbilical artery Doppler pulsatility index and childhood neurocognitive outcome at 12 years
| Autor: | Andrew Thompson, Barbara McConnell, James Dornan, Stephen Ong, Fionnuala Mone, Fionnuala M. McAuliffe, Michael D. Shields, Peter Hepper, Ricardo Segurado, Moira Stewart |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Neurocognitive Disorders Gestational Age Placental insufficiency Ultrasonography Prenatal Umbilical Arteries 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics medicine Humans Placental Circulation Prospective Studies Prospective cohort study Child Psychiatric Status Rating Scales Fetus 030219 obstetrics & reproductive medicine business.industry Obstetrics Research Case-control study Gestational age Ultrasonography Doppler Paediatrics General Medicine medicine.disease United Kingdom Logistic Models Case-Control Studies Pulsatile Flow Linear Models Gestation Female business Neurocognitive Biomarkers Follow-Up Studies |
| Zdroj: | BMJ Open Mone, F, McConnell, B, Thompson, A, Segurado, R, Hepper, P, Stewart, M C, Dornan, J C, Ong, S, McAuliffe, F M & Shields, M D 2016, ' Fetal umbilical artery Doppler pulsatility index and childhood neurocognitive outcome at 12 years ', BMJ Open, vol. 6, no. 6 . https://doi.org/10.1136/bmjopen-2015-008916 |
| ISSN: | 2044-6055 |
| Popis: | OBJECTIVE: To determine whether an elevated fetal umbilical artery Doppler (UAD) pulsatility index (PI) at 28 weeks' gestation, in the absence of fetal growth restriction (FGR) and prematurity, is associated with adverse neurocognitive outcome in children aged 12 years.METHODS: Prospective cohort study, comparing children with a normal fetal UAD PI (RESULTS: The mean age of follow-up was 12.4 years (±0.5 SD) with 44% of children male (n=63). When UAD was assessed at 28 weeks, the elevated fetal UAD group had lower scores in cognitive assessments of information processing and memory. Parameters included (1) recall of objects immediate verbal (p=0.002), (2) delayed verbal (p=0.008) and (3) recall of objects immediate spatial (p=0.0016). There were no significant differences between the Doppler groups at 32 or 34 weeks' gestation.CONCLUSIONS: An elevated UAD PI at 28 weeks' gestation in the absence of FGR or prematurity is associated with lower scores of declarative memory in children aged 12 years. A potential explanation for this is an element of placental insufficiency in the presence of the appropriately grown fetus, which affects the development of the fetal hippocampus and information processing and memory long-term. These findings, however, had no impact on overall academic ability, mental processing and reasoning or overall behavioural function. |
| Databáze: | OpenAIRE |
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