Multivariate analysis in the development of bioequivalent tablets containing bicalutamide
| Autor: | Petr Sova, Pavel Farkaš, Roman Goněc, Aleš Franc, Petr Doležel |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Multivariate statistics
Multivariate analysis Bicalutamide Chemistry Pharmaceutical Pharmaceutical Science Biological Availability 02 engineering and technology Bioequivalence 030226 pharmacology & pharmacy Tosyl Compounds 03 medical and health sciences 0302 clinical medicine Nitriles medicine Econometrics Anilides Pharmaceutical industry Mathematics business.industry General Medicine 021001 nanoscience & nanotechnology Therapeutic Equivalency Multivariate Analysis 0210 nano-technology business medicine.drug Tablets |
| Zdroj: | Pharmaceutical development and technology. 26(1) |
| ISSN: | 1097-9867 |
| Popis: | The pharmaceutical industry has to tackle the explosion of high amounts of poorly soluble APIs. This phenomenon leads to numerous sophisticated solutions. These include the use of multifactorial data analysis identifying correlations between the components and dosage form properties, laboratory and production process parameters with respect to the API liberation Example of such API is bicalutamide. Improved liberation is achieved by particle size reduction. Laboratory batches, with different PSD of API, were filled into gelatinous capsules and consequently granulated for tablet compression. Comparative dissolution profiles with Casodex 150 mg (Astra Zeneca) were performed. The component analysis was used for the statistical evaluation of |
| Databáze: | OpenAIRE |
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