Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists

Autor:	Ronald Palin, Hardy Sundaram, Philip S. Jones, David Vrolijk, Louise Evans, Mark A. Weston, David R. Barn, Grove Simon James Anthony, Helen Feilden, John K. Clark, J. Cottney, Marc Crockatt, Alasdair R.C. Smith, Grant Wishart, Paul Wren, Phillip M. Cowley, Richard Morphy, Frank Griekspoor, Richard R. Goodwin, Andrea K. Houghton
Rok vydání:	2005
Předmět:	Male Agonist Stereochemistry medicine.drug_class Clinical Biochemistry NOP Pharmaceutical Science CHO Cells Transfection Biochemistry Chemical synthesis Nociceptin Receptor Inhibitory Concentration 50 Mice Structure-Activity Relationship chemistry.chemical_compound Vas Deferens Piperidines Cricetinae Drug Discovery Cyclic AMP medicine Animals Humans Receptor Molecular Biology Organic Chemistry In vitro Nociceptin receptor chemistry Drug Design Receptors Opioid Molecular Medicine Piperidine Hydrophobic and Hydrophilic Interactions ORL1 receptor
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 15:589-593
ISSN:	0960-894X
Popis:	A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43590a4562dd3711ecd7e4e22da1580f https://doi.org/10.1016/j.bmcl.2004.11.049 Zobrazit plný text záznamu Full Text from ScienceDirect