Gastric cancer in young patients: a separate entity with aggressive features and poor prognosis
| Autor: | Wenhui Wu, Changhua Zhang, Zi Chong Kuo, Lyu‐jia Cheng, Chuangqi Chen, Songyao Chen, Sijun Meng, Zhewei Wei, Yulong He |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Poor prognosis medicine.medical_specialty Multivariate analysis Adolescent medicine.medical_treatment Adenocarcinoma Gastroenterology Disease-Free Survival 03 medical and health sciences Young Adult 0302 clinical medicine Stomach Neoplasms Internal medicine medicine Humans Stage (cooking) Neoadjuvant therapy Aged Hematology business.industry Incidence (epidemiology) Hazard ratio Age Factors Cancer General Medicine Middle Aged medicine.disease Prognosis 030104 developmental biology Oncology 030220 oncology & carcinogenesis Female business |
| Zdroj: | Journal of cancer research and clinical oncology. 146(11) |
| ISSN: | 1432-1335 |
| Popis: | To investigate the clinicopathological features and survival outcomes between young and old patients with gastric cancer (GC), and further determine the role of young age in the prognosis of GC. Patients with stage I–III gastric adenocarcinomas undergoing curative surgery were enrolled, divided into young (aged 18–49 years, YG), middle-aged (50–59 years, MG), and old (≥ 60 years, OG) groups. Exclusion criteria were neoadjuvant therapy and history of malignant tumors. Clinicopathological features, overall survival (OS), disease-free survival (DFS), and recurrence patterns were compared among three groups. 1131 patients were finally included, with 270, 314, and 547 cases in the YG, MG, and OG, respectively. Compared to others, YG had higher proportion of female, middle-third gastric cancer, poor differentiation, N3b stage, and adjuvant chemotherapy. YG demonstrated poorer 5-year OS than MG (62.4% vs. 70.8%, P = 0.019), but better than OG (62.4% vs. 58.7%, P = 0.031). YG also suffered inferior 5-year DFS (75.2% vs. 82.8%, P = 0.040) compared with MG, and higher incidence of peritoneal recurrence than MG (15.1% vs. 5.2%, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink