Polymeric IgA paraprotein on agarose gel electrophoresis immunofixation identifies a unique subset of IgA myeloma patients
| Autor: | Adrian Y.S. Lee, Ming-Wei Lin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Immunofixation medicine.medical_specialty Clinical Biochemistry Biochemistry Gastroenterology 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans Prospective Studies Multiple myeloma Retrospective Studies Electrophoresis Agar Gel Proteinuria biology business.industry Biochemistry (medical) Australia General Medicine Polymeric IgA IgA myeloma medicine.disease Immunoglobulin A Cross-Sectional Studies 030104 developmental biology 030220 oncology & carcinogenesis Agarose gel electrophoresis biology.protein Paraproteins medicine.symptom Multiple Myeloma business |
| Zdroj: | Clinica Chimica Acta. 512:112-116 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2020.10.031 |
| Popis: | Objectives On agarose gel electrophoresis, IgA paraprotein has a tendency to polymerise and form multiple bands on immunofixation. We decided to investigate if there are any differences in clinical parameters with monomeric vs. polymeric IgA paraprotein multiple myeloma (MM) patients. Methods During an 18-month retrospective and prospective cross-sectional audit review period at one Australian laboratory, we identified 92 IgA MM patients that were divided up according to monomeric or polymeric IgA paraproteins based on their appearance on IFE. Medical and pathology records were reviewed for demographic details, and laboratory data to examine for end-organ manifestations of MM. Results After correcting for age, polymeric IgA MM patients had a greater degree of proteinuria and hence, higher incidence of hypogammaglobulinaemia. The patients tended to have a higher quantity of paraprotein as well. No difference in mortality was seen. Conclusions Our study is the first to stratify IgA MM patients according to the laboratory appearance of their paraprotein and may hold important prognostic and predictive clues for these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect