Caution, 'normal' BMI: health risks associated with potentially masked individual underweight-EPMA Position Paper 2021

Autor: Maria E. Evsevyeva, Rostyslav V Bubnov, Carl Erb, Anatolij A. Kunin, Dieter Felbel, Niva Shapira, Dietrich Büsselberg, Detlef E. Dietrich, Kamil Biringer, Holger Fröhlich, Friedemann Paul, Martin Hofmann-Apitius, Halina Podbielska, Olga Golubnitschaja, Lenka Koklesova, Alena Liskova, Alexander Karabatsiakis, Colin Birkenbihl, Jiri Polivka, Marek Samec, Peter Kubatka
Rok vydání: 2021
Předmět:
Gerontology
Weight loss
Youth
Anthropometrics
Non-communicable disorders
Reproductive dysfunction
Deficits
Disease
Overweight
Elderly
BMI deviation
Pregnancy
Drug Discovery
Health care
Pathology
Medicine
Underweight
Individualised patient profile
education.field_of_study
Big data management
Anorexia athletica
Progression
Endothelin-1
Healthcare
Population health
ROS
Cardiovascular disease
Health policy
Hypoxic effects
Stroke
Unintentional
Body fluids
Flammer syndrome
Neurology
Metabolic pathways
Medical imaging
medicine.symptom
Cancers
Intentional
Manifestation
Systemic ischemia
Communicable
Population
Well-being
Multi-parametric analysis
Wound healing
Innovative population Screening Programme
Modelling
Adults
Artificial intelligence in medicine
Molecular patterns
Disease development
Neurodegeneration
education
Health economy
Nutrition
Inflammation
business.industry
Research
Biochemistry (medical)
COVID-19
Body weight
Biomarker panel
Immune system
Vasoconstriction
Fat
Multi-level diagnostics
Sports medicine
Microbiome
Predictive preventive personalised medicine (3PM/PPPM)
business
Body mass index
Zdroj: The EPMA Journal
ISSN: 1878-5077
Popis: An increasing interest in a healthy lifestyle raises questions about optimal body weight. Evidently, it should be clearly discriminated between the standardised “normal” body weight and individually optimal weight. To this end, the basic principle of personalised medicine “one size does not fit all” has to be applied. Contextually, “normal” but e.g. borderline body mass index might be optimal for one person but apparently suboptimal for another one strongly depending on the individual genetic predisposition, geographic origin, cultural and nutritional habits and relevant lifestyle parameters—all included into comprehensive individual patient profile. Even if only slightly deviant, both overweight and underweight are acknowledged risk factors for a shifted metabolism which, if being not optimised, may strongly contribute to the development and progression of severe pathologies. Development of innovative screening programmes is essential to promote population health by application of health risks assessment, individualised patient profiling and multi-parametric analysis, further used for cost-effective targeted prevention and treatments tailored to the person. The following healthcare areas are considered to be potentially strongly benefiting from the above proposed measures: suboptimal health conditions, sports medicine, stress overload and associated complications, planned pregnancies, periodontal health and dentistry, sleep medicine, eye health and disorders, inflammatory disorders, healing and pain management, metabolic disorders, cardiovascular disease, cancers, psychiatric and neurologic disorders, stroke of known and unknown aetiology, improved individual and population outcomes under pandemic conditions such as COVID-19. In a long-term way, a significantly improved healthcare economy is one of benefits of the proposed paradigm shift from reactive to Predictive, Preventive and Personalised Medicine (PPPM/3PM). A tight collaboration between all stakeholders including scientific community, healthcare givers, patient organisations, policy-makers and educators is essential for the smooth implementation of 3PM concepts in daily practice.
Databáze: OpenAIRE
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