Two Canine Papillomaviruses Associated With Metastatic Squamous Cell Carcinoma in Two Related Basenji Dogs
| Autor: | Michelle Marie Mader, Carolyn F. Orr, P. Rowland, Jennifer Luff, Hang Yuan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Skin Neoplasms 040301 veterinary sciences In situ hybridization Polymerase Chain Reaction DNA sequencing law.invention Malignant transformation 0403 veterinary science 03 medical and health sciences Dogs Antigen law medicine Animals Dog Diseases Papillomaviridae Gene In Situ Hybridization Polymerase chain reaction Skin General Veterinary biology Papillomavirus Infections 04 agricultural and veterinary sciences biology.organism_classification 030104 developmental biology Carcinoma Squamous Cell Immunohistochemistry |
| Zdroj: | Veterinary Pathology. 53:1160-1163 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/0300985816630795 |
| Popis: | Papillomaviruses (PV) are associated with benign mucosal and cutaneous epithelial proliferations. In dogs, PV-associated pigmented plaques and papillomas can undergo malignant transformation, but this is rare, and most cases of canine squamous cell carcinoma do not arise from PV-induced precursor lesions. We describe herein the progression of pigmented plaques to invasive and metastatic squamous cell carcinoma associated with 2 canine papillomaviruses (CPV) in 2 related Basenji dogs. Immunohistochemistry for PV antigen revealed strong nuclear immunoreactivity within keratinocytes from pigmented plaques from both dogs, consistent with a productive viral infection. Polymerase chain reaction (PCR) using degenerate primers for the L1 gene revealed PV DNA sequences from 2 different CPVs. In situ hybridization for CPV revealed strong hybridization signals within the pigmented plaques and neoplastic squamous epithelial cells from both dogs. We report here progression of PV-associated pigmented plaques to metastatic squamous cell carcinoma within 2 Basenji dogs associated with 2 different CPVs. |
| Databáze: | OpenAIRE |
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