Is low level laser therapy or ozone therapy more effective for bone healing? Understanding the mechanisms of HIF-1α, RANKL and OPG

Autor:	P Hacisalihoglu, S Bayer Alinca, Mehmet Ali Dogan, Ebru Saglam, T Zengin Celik
Rok vydání:	2020
Předmět:	Male 0301 basic medicine medicine.medical_specialty Histology medicine.medical_treatment Alveolar Bone Loss Urology Bone healing 03 medical and health sciences Oxidants Photochemical Ozone 0302 clinical medicine Osteoprotegerin medicine Animals Low-Level Light Therapy Rats Wistar Periodontitis Dental alveolus Low level laser therapy 030102 biochemistry & molecular biology biology business.industry General Medicine medicine.disease Ozone therapy Rats Medical Laboratory Technology RANKL 030220 oncology & carcinogenesis biology.protein Immunohistochemistry business
Zdroj:	Biotechnic & Histochemistry. 95:597-604
ISSN:	1473-7760 1052-0295
Popis:	Periodontitis is a common chronic infection of dental tissues. Ozone therapy (OT) and low level laser therapy (LLLT) are useful treatments for periodontitis. We investigated the effects of OT and LLLT on periodontal disease-induced bone destruction in rats with experimentally induced periodontitis (EP). We used 30 male Wistar rats divided into three groups: control, OT and LLLT. EP was induced by placing a 3.0 silk suture around the cervix of the left mandibular first molar tooth. OT was performed using an ozone generator at 80% concentration. LLLT was applied using a diode laser. Both OT and LLLT were performed for two weeks at two day intervals. Histomorphometric and immunohistochemical analyses also were performed. Alveolar bone loss was significantly less in the LLLT group compared to the control group. The number of HIF-1α positive cells was significantly less in the LLLT group compared to the control group. We found significantly fewer RANKL-positive cells in the OT group compared to the control group. The number of osteoprotegerin (OPG) positive cells was significantly greater for the LLLT group than for the control group. Although both treatments produced positive effects, LLLT appears to be more effective for increasing alveolar bone formation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43242957b2f345d1f255559c47aedc4b https://doi.org/10.1080/10520295.2020.1743360 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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