Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression
| Autor: | Mark A. Frye, Joseph Ventura, Jason W. Chirichigno, Irwin Walot, M. Albert Thomas, Jeffrey Fischer, June Watzl, Shana Elman, John Tsuang, Pablo Davanzo, Jim Mintz, Joseph O'Neill, Shida Banakar |
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| Rok vydání: | 2007 |
| Předmět: |
Cingulate cortex
In vivo magnetic resonance spectroscopy Adult Male medicine.medical_specialty Bipolar Disorder Magnetic Resonance Spectroscopy medicine.drug_class Glutamic Acid Prefrontal Cortex Lamotrigine Creatine Gyrus Cinguli Phosphocreatine chemistry.chemical_compound Internal medicine medicine Humans Pharmacology Analysis of Variance business.industry Triazines Mood stabilizer Middle Aged Antidepressive Agents Glutamine Psychiatry and Mental health Psychotropic drug Endocrinology chemistry Evaluation Studies as Topic Female Protons business Neuroscience medicine.drug |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 32(12) |
| ISSN: | 0893-133X |
| Popis: | Proton magnetic resonance spectroscopy ((1)HMRS) is an in vivo brain imaging method that can be used to investigate psychotropic drug mechanism of action. This study evaluated baseline (1)HMRS spectra of bipolar depressed patients and whether the level of cerebral metabolites changed after an open trial of lamotrigine, an anti-glutamatergic mood stabilizer. Twenty-three bipolar depressed and 12 control subjects underwent a MRS scan of the anterior cingulate/medial prefrontal cortex. The scan was performed on a GE whole-body 1.5 T MRI scanner using single-voxel PRESS (TE/TR=30/3000 ms, 3 x 3 x 3 cm(3) and post-processed offline with LCModel. Baseline CSF-corrected absolute concentrations of glutamate+glutamine ([Glx]), glutamate ([Glu]), and creatine+phosphocreatine ([Cr]) were significantly higher in bipolar depressed subjects vs healthy controls. The non-melancholic subtype had significantly higher baseline [Glx] and [Glu] levels than the melancholic subtype. Remission with lamotrigine was associated with significantly lower post-treatment glutamine ([Gln]) in comparison to non-remission. These data suggest that non-melancholic bipolar depression is characterized by increased glutamate coupled with increased energy expenditure. Lamotrigine appears to reduce glutamine levels associated with treatment remission. Further study is encouraged to determine if these MR spectroscopic markers can delineate drug mechanism of action and subsequent treatment response. |
| Databáze: | OpenAIRE |
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