The Diversification of Cell Death and Immunity: Memento Mori
| Autor: | Maria Konstantinou, Pascal Meier, Emily F. Goode, Arnaud J. Legrand |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Programmed cell death
Necroptosis medicine.medical_treatment Antineoplastic Agents Apoptosis Biology 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Immune system Immunity Neoplasms Pyroptosis medicine Animals Ferroptosis Humans Molecular Biology 030304 developmental biology Oncolytic Virotherapy 0303 health sciences Cell Biology Immunotherapy Chronic infection Cellular Microenvironment Tumor Escape Apoptosis Regulatory Proteins Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Molecular Cell. 76:232-242 |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/j.molcel.2019.09.006 |
| Popis: | Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and multiplied to cover the complexity of the foes the immune system faces. In this review, we discuss the different types of cell death, the underlying signaling events, and their unequal ability to trigger an immune response. We also comment on how to use our knowledge of cell death signaling to improve the efficacy of cancer treatment. We argue that cell death is integral to the immune response and acts as a beacon, a second messenger, that guides both immune system and tissue micro-environment to ensure tissue repair and homeostasis. Memento mori-"remember you must die"-as failure to do so opens the way to chronic infection and cancer. |
| Databáze: | OpenAIRE |
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