Evaluation of natural killer cell (CD57) as a prognostic marker in oral squamous cell carcinoma: An immunohistochemistry study
| Autor: | Minal Chaudhary, Shree Bajaj, Shruti Bohra, Rashmi Agarwal |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Group ii Labeling index Biology Pathology and Forensic Medicine Natural killer cell 03 medical and health sciences 0302 clinical medicine Oral and maxillofacial pathology medicine Basal cell In patient General Dentistry Innate immune system natural killer cell oral cancer medicine.disease oral squamous cell carcinoma stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Immunohistochemistry Original Article CD57 |
| Zdroj: | Journal of Oral and Maxillofacial Pathology : JOMFP |
| ISSN: | 0973-029X |
| Popis: | Objectives: Natural killer (NK) cells are important effector lymphocytes. NK cells are considered to represent innate immune system. NK cells target and kill aberrant cells such as virally infected and tumorigenic cells. The purpose of this study was to assess the expression of CD57 in oral squamous cell carcinoma (OSCC) and to correlate the expression of CD57 with 3 years survival in patients with OSCC. Materials and Methods: About 100 histopathologically diagnosed cases of OSCC of various grades were divided into two groups, i.e., Group I (dead patients) and Group II (live patients) from the archives of Department of Oral Pathology and Microbiology. CD57 was detected in these tissues by immunohistochemistry. Result: The results were analyzed using Spearman's correlation coefficient and students unpaired t-test. The mean CD57 labeling index in Group II was significantly higher than that found in Group I (P = 0.000). There was a significant correlation (P = 0.00) in the mean CD57 levels between Groups I and II and prognosis of patient. Conclusion: CD57 could be a good prognostic marker for OSCC patients. |
| Databáze: | OpenAIRE |
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