Liposomal Bleomycin: Increased Therapeutic Activity and Decreased Pulmonary Toxicity in Mice
| Autor: | D Bechtel, D. Arndt, R Zeisig, Iduna Fichtner |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Lung Diseases
Materials science Pulmonary toxicity Pharmaceutical Science Polyethylene glycol Lung injury Pharmacology Bleomycin Mice chemistry.chemical_compound Drug Delivery Systems Phosphatidylcholine Animals Lung Liposome Antibiotics Antineoplastic Dose-Response Relationship Drug Lewis lung carcinoma Neoplasms Experimental General Medicine respiratory system respiratory tract diseases carbohydrates (lipids) chemistry Liposomes Toxicity Female |
| Zdroj: | Drug Delivery. 8:1-7 |
| ISSN: | 1521-0464 1071-7544 |
| Popis: | Conventional and sterically stabilized liposomes derived from phosphatidylcholine or the antitumor agents, hexadecylphosphocholine and octadecyl-(1,1-dimethyl-4-piperidino-4-yl)-phosphate, as bilayer forming constituents, containing bleomycin, were developed and tested. Liposomal encapsulation of bleomycin enhanced strongly the antitumor activity against P388 leukemia and the Lewis lung carcinoma. This effect was clearly dependent on the size and lipid composition of the bleomycin-containing liposomes. The therapeutic effects were nearly equal for liposomal and free bleomycin in the B16 melanoma. The partial replacement of phosphatidylcholine by alkylphospholipids and the inclusion of polyethylene glycol modified lipids for sterical stabilization did not further improve the therapeutic efficacy but increased, in some cases, the toxicity of liposomes. Bleomycin-induced lung injury was not observed if liposomal bleomycin was administered. |
| Databáze: | OpenAIRE |
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