Treatment of experimental liver metastases with a noncontact neodymium: YAG laser
| Autor: | Will J. Kort, Marcel Vermeij, Onno T. Terpstra, Richard van Hillegersberg |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pathology
medicine.medical_specialty Time Factors chemistry.chemical_element Light Coagulation Neodymium law.invention Metastasis Colon carcinoma law Animals Medicine Yttrium business.industry Liver Neoplasms Laser medicine.disease Rats Coagulative necrosis chemistry Regression Analysis Neodymium-YAG laser Surgery Multiple linear regression analysis business Aluminum |
| Zdroj: | Journal of Surgical Research. 53:128-135 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/0022-4804(92)90024-t |
| Popis: | The extent of tumor and liver damage after treatment with the neodymium:yttrium-aluminum-garnet (Nd:YAG) laser was investigated in a rat tumor model. Colon carcinoma CC531 was implanted in the liver and treated with 60 J (14 tumors), 120 J (15 tumors), or 180 J (12 tumors) at a power setting of 20 W. To assess the effects upon the tissues three animals were sacrificed immediately after treatment and 1, 2, 4, and 8 days later. Sections from the tumor sites were evaluated by light microscopy and the maximal depth and width of different zones of tissue damage were measured. Laser effects could be determined most accurately on Days 1 and 2 after treatment. Multiple linear regression analysis of the data indicated a linear relationship between laser energy and depth of tumor damage (P less than 0.01). The results of this study show the potential of the Nd:YAG laser to produce tumor coagulation necrosis with minimal liver necrosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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