A 3'-UTR Polymorphism in Soluble Epoxide Hydrolase Gene Is Associated with Acute Rejection in Renal Transplant Recipients
| Autor: | Emilio Doblaré, Maria Jesús Fernández-Cavada, Guillermo Gervasini, Montserrat García-Cerrada, Juan José Cubero, Beatriz Suarez-Alvarez, Carmen Díaz-Corte, Esther Vergara, Eliecer Coto, Sergio Espuelas Barroso, Raúl Alvarado, Guadalupe García-Pino, Carlos López-Larrea |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Epoxide hydrolase 2
Epoxide Hydrolases Graft Rejection Multidisciplinary Graft rejection lcsh:R lcsh:Medicine Biology Middle Aged Molecular biology Kidney Transplantation Polymorphism Single Nucleotide Tissue Donors Biochemistry Renal transplant cardiovascular system Humans lipids (amino acids peptides and proteins) lcsh:Q lcsh:Science 3' Untranslated Regions Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 7, p e0133563 (2015) Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid PLoS ONE Scopus RUO. Repositorio Institucional de la Universidad de Oviedo instname |
| ISSN: | 1932-6203 |
| Popis: | Background and Purpose Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that play a protective role against damaging processes that may occur after re-oxygenation of the graft. We aimed to investigate whether the presence of functional polymorphisms in the gene encoding soluble epoxy hydrolase (EPHX2), which metabolizes EETs to less active compounds, may play a role in the outcome of renal transplantation. Methods In a group of 259 Caucasian renal transplant recipients and 183 deceased donors, we determined the presence of three common EPHX2 SNPs, namely rs41507953 (K55R), rs751141 (R287Q) and rs1042032 A/G. Associations with parameters of graft function and the incidence of acute rejection were retrospectively investigated throughout the first year after grafting by logistic regression adjusting for clinical and demographic variables. Results Carriers of the rs1042032 GG genotype displayed significantly lower estimated glomerular filtration rate (eGFR) (38.15 ± 15.57 vs. 45.99 ± 16.05; p = 0.04) and higher serum creatinine values (1.57 ± 0.58 vs. 1.30 ± 0.47 g/dL; p=0.02) one year after grafting, compared to patients carrying the wildtype A-allele. The same GG genotype was also associated to increased risk of acute rejection. Interestingly, this association was observed for the genotype of both recipients [OR =6.34 (1.35-29.90); p = 0.015] and donors [OR = 5.53 (1.10-27.80); p=0.042]. A statistical model including both genotypes along with other meaningful demographic and clinical variables resulted in an increased significance for the association with the recipients’ genotype [OR=8.28 (1.21-74.27); p=0.031]. Conclusions Our results suggest that genetic variability in the EETs-metabolizing gene, EPHX2, may have a significant impact on the outcome of deceased-donor renal transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|