Susceptibility of Psammomys obesus and Meriones tristrami to tachyzoites of Neospora caninum
| Autor: | I. Savitsky, Varda Shkap, U. Orgad, S. Perl, L. Fish, E. Pipano |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Antibodies Protozoan Pleural exudate Peritonitis Parasitemia Microbiology Apicomplexa Meriones tristrami Mice Animals Ecology Evolution Behavior and Systematics biology Inoculation Coccidiosis Neospora biology.organism_classification Neospora caninum Rats Fibrinous peritonitis Fluorescent Antibody Technique Direct Immunology Protozoa Parasitology Female Psammomys Disease Susceptibility Gerbillinae |
| Zdroj: | The Journal of parasitology. 88(2) |
| ISSN: | 0022-3395 |
| Popis: | The susceptibility of Psammomys obesus (sand rat) and Meriones tristrami (Tristram's jird) to Neospora caninum was investigated by subcutaneous (s.c.) and intraperitoneal (i.p.) inoculation of 10-fold doses of culture-derived tachyzoites. Groups of 5 animals were inoculated with doses of 10-10(7) parasites via each route of inoculation. All but 2 of the sand rats inoculated with doses of 10-10(4) parasites succumbed to the infection by 7-18 days postinfection. All jirds inoculated with 10(7) tachyzoites succumbed by 5-16 days postinfection and those inoculated with 10(6) tachyzoites by 9-25 days. A considerable proportion of the jirds inoculated with 10-10(5) tachyzoites survived. Fibrinous peritonitis with ascites containing numerous tachyzoites was observed in the i.p.-inoculated sand rats and jirds that succumbed to the infection. In the jirds, tachyzoites were also found in pleural exudate. A considerable number (42.8%) of the jirds inoculated s.c. or i.p. exhibited neuromuscular symptoms, expressed in ataxia, head tilt, circling movement, and posterior paralysis. Seven successive passage of tachyzoites were achieved in sand rats with doses of 10(5) parasites and in jirds with doses of 10(7) parasites. All surviving jirds became seroconverted and were immune to lethal challenge. |
| Databáze: | OpenAIRE |
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