T cell receptor diversity, specificity and promiscuity of functionally heterogeneous human MR1-restricted T cells
| Autor: | Deborah A. Lewinsohn, Marco Lepore, David M. Lewinsohn |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chemistry
Ligand Receptors Antigen T-Cell alpha-beta Histocompatibility Antigens Class I Immunology Cell T-cell receptor Receptors Antigen T-Cell MAIT Cells T-Cell Antigen Receptor Specificity Computational biology Small molecule Mucosal-Associated Invariant T Cells Article Minor Histocompatibility Antigens medicine.anatomical_structure Promiscuity Antigen T-Lymphocyte Subsets medicine Humans Immunity Mucosal Molecular Biology Alpha chain |
| Zdroj: | Mol Immunol |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/j.molimm.2020.12.009 |
| Popis: | The monomorphic MHC-class I-like molecule, MR1, presents small metabolites to T cells. MR1 is the restriction element for microbe-reactive mucosal-associated invariant T (MAIT) cells. MAIT cells have limited TCR usage, including a semi-invariant TCR alpha chain and express high levels of CD161 and CD26. In addition to microbial lumazine metabolites, recent studies have demonstrated that MR1 is able to capture a variety of diverse chemical entities including folate-derivatives, a number of drug-like and other synthetic small molecules, and as yet undefined compounds of self-origin. This capacity of MR1 to bind distinct ligands likely accounts for the recent identification of additional, non-canonical, subsets of MR1-restricted T (MR1T) cells. These subsets can be defined based on their ability to recognize diverse microbes as well as their reactivity to non-microbial cell-endogenous ligands, including tumor-associated antigens. Herein, we will discuss our current understanding of MR1T cell diversity in terms of TCR usage, ligand recognition and functional attributes (Table I). |
| Databáze: | OpenAIRE |
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