Echoplanar diffusion-weighted MRI with intravenous gadolinium-DTPA
| Autor: | D. Sauner, Clemens Fitzek, Hans-Joachim Mentzel, Sabine Fitzek, Werner A. Kaiser, Jürgen R. Reichenbach |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Neurology Gadolinium chemistry.chemical_element Contrast Media Brain Ischemia Central nervous system disease Route of administration Medicine Humans Radiology Nuclear Medicine and imaging Single-Blind Method cardiovascular diseases Prospective Studies Prospective cohort study Infusions Intravenous Neuroradiology Aged Observer Variation medicine.diagnostic_test business.industry Brain Neoplasms Echo-Planar Imaging Reproducibility of Results Magnetic resonance imaging Middle Aged medicine.disease chemistry Blood-Brain Barrier Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Nuclear medicine Intracranial Hemorrhages Diffusion MRI |
| Zdroj: | Neuroradiology. 45(9) |
| ISSN: | 0028-3940 |
| Popis: | It is occasionally necessary to repeat diffusion weighted imaging (DWI) after giving intravenous contrast medium (CM). However, the effects of CM on DWI and apparent diffusion coefficients (ADC) have not been fully examined. The aim of this prospective study was to investigate whether there are any diagnostically significant differences between echo-planar imaging (EPI)-DWI before and after intravenous CM. EPI-DWI was acquired twice in 203 consecutive patients before and after i.v. CM. Three blinded readers rated the diagnostic image quality. Quantitative ADC calculations were performed before and after CM in all 72 patients with lesions sufficiently large for quantification, and in 72 normal brain regions. Of the 203 patients, 127 had abnormalities on MRI, including ischaemic stroke (52), bleeding (nine), brain tumour with disturbed blood-brain barrier (BBB) (18) and other lesions (48). There were no significant signal differences on isotropic DWI before and after CM, even in lesions with definite disturbance of the BBB. No statistically significant difference between ADC of lesions and contralateral normal brain was observed. |
| Databáze: | OpenAIRE |
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