Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Versus Negative Patients
| Autor: | Elizabeth R. Felix, Anat Galor, Konstantinos D. Sarantopoulos, Allison L. McClellan, Nicole L. Lanza, Roy C. Levitt, Hatim Batawi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures Cross-sectional study Positive / Elevated Point-of-Care Systems Point-of-care testing Population Keratoconjunctivitis Sicca Dry Eye Syndromes Article 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires Ophthalmology Humans Medicine In patient education Veterans Affairs education.field_of_study business.industry Matrix metalloproteinase 9 eye diseases Cross-Sectional Studies 030104 developmental biology Matrix Metalloproteinase 9 030221 ophthalmology & optometry sense organs business |
| Zdroj: | The Ocular Surface. 14:216-223 |
| ISSN: | 1542-0124 |
| DOI: | 10.1016/j.jtos.2015.12.007 |
| Popis: | Purpose To compare dry eye (DE) symptoms and signs in subjects who tested positive versus those who tested negative for ocular surface matrix metalloproteinase 9 ( MMP-9 ) using the InflammaDry point-of-care test (RPS, Sarasota, FL). Methods In this cross-sectional study, individuals seen in the Miami Veterans Affairs eye clinic with DE symptoms, as evidenced by DE questionnaire 5 ( DEQ5 ) ≥6, were given standardized questionnaires to assess DE symptoms and ocular and non-ocular pain complaints. Also, a complete evaluation was conducted to measure ocular surface signs of DE. MMP-9 testing was performed using the InflammaDry once in each eye, per the manufacturer's instructions. The main outcome measure was a comparison of DE symptoms and signs in MMP-9 positive versus negative subjects. Results Of 128 subjects, 50 (39%) were positive for MMP-9 for InflammaDry testing in either eye. No statistically significant differences in mental health indices, DE symptoms, or ocular surface signs were seen in subjects based on MMP-9 status. Conclusion In our population, there was no difference in the DE profile by both symptoms and signs between those testing positive versus negative for MMP-9 on the ocular surface. This suggests that clinical exam alone cannot predict patients with clinically significant inflammation. |
| Databáze: | OpenAIRE |
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