Preoperative plasma level of endoglin as a predictor for disease outcomes after radical cystectomy for nonmetastatic urothelial carcinoma of the bladder
| Autor: | Marco Moschini, Kristin Zimmermann, Nico С. Grossmann, Hadi Mostafaei, Dmitry Enikeev, Harun Fajkovic, Reza Sari Motlagh, Pawel Rajwa, David D`Andrea, Péter Nyirády, Keiichiro Mori, Flora Zeinler, Shahrokh F. Shariat, Victor M. Schuettfort, Pierre I. Karakiewicz, Benjamin Pradere, Fahad Quhal, Michael Rink, Ekaterina Laukhtina, Douglas S. Scherr, Satoshi Katayama, Mohammad Abufaraj, Eva Compérat |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Urology Disease Biology Cystectomy otorhinolaryngologic diseases medicine Biomarkers Tumor Humans Prospective Studies Molecular Biology Urothelial carcinoma Aged Neoplasm Staging Carcinoma Transitional Cell Bladder cancer Proportional hazards model Endoglin Plasma levels Middle Aged medicine.disease Prognosis Survival Analysis Gene Expression Regulation Neoplastic Treatment Outcome Urinary Bladder Neoplasms Preoperative Period Biomarker (medicine) Lymph Node Excision Female |
| Zdroj: | Molecular carcinogenesis. 61(1) |
| ISSN: | 1098-2744 |
| Popis: | Elevated preoperative plasma level of endoglin has been associated with worse oncologic outcomes in various malignancies. The present large-scale study aimed to determine the predictive and prognostic values of preoperative endoglin with regard to clinicopathologic and survival outcomes in patients treated with radical cystectomy (RC) for nonmetastatic urothelial carcinoma of the bladder (UCB). We prospectively collected preoperative blood samples from 1036 consecutive patients treated with RC for UCB. Logistic and Cox regression analyses were undertaken to assess the correlation of endoglin levels with pathologic and survival outcomes, respectively. The AUC and C-index were used to assess the discrimination. Patients with adverse pathologic features had significantly higher median preoperative endoglin plasma levels than their counterparts. Higher preoperative endoglin level was independently associated with an increased risk for lymph node metastasis, ≥pT3 disease, and nonorgan confined disease (NOCD; all p |
| Databáze: | OpenAIRE |
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