Accelerated schedule of hepatitis B vaccination in high-risk youth
| Autor: | Wilkinson Se, Bennett Dl, Morath M, Burgess Ma, David Isaacs |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Vaccination schedule medicine.disease_cause Serology Risk Factors medicine Humans Hepatitis B Vaccines Immunization Schedule Hepatitis B virus business.industry Hepatitis B medicine.disease Confidence interval Vaccination Immunization Pediatrics Perinatology and Child Health Immunology Patient Compliance Female Viral disease New South Wales business |
| Zdroj: | Journal of Paediatrics and Child Health. 32:60-62 |
| ISSN: | 1440-1754 1034-4810 |
| DOI: | 10.1111/j.1440-1754.1996.tb01544.x |
| Popis: | Objective: To perform a feasibility and immunogenicity study of an accelerated schedule of hepatitis B immunization for high-risk youth. Methodology: High-risk adolescents attending a youth health centre and nearby youth refuges were immunized with Engerix-B recombinant vaccine, 20 μg intramuscularly, at 0,2 and 6 weeks. Serology was performed prior to immunization and 3 months after the third dose. Results: Forty-two subjects (27 female) aged 13-20 years entered the study. Two (4.8%), already hepatitis B virus (HBV) seropositive, were excluded. Thirty-six of 40 subjects had one or more risk factors for HBV. Participants were often elusive, needing multiple attempts to establish contact. Twenty (50%) of the 40 completed three immunizations and all 14 studied developed anti-hepatitis B surface titres of > 100mlU/mL (geometric mean titre 630 mIU/mL, 95% confidence intervals 309-1290). Conclusion: High-risk youth can be immunized against hepatitis B successfully using an accelerated schedule, but compliance is difficult. |
| Databáze: | OpenAIRE |
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