Urinary Cystatin C as a Potential Risk Marker for Cardiovascular Disease and Chronic Kidney Disease in Patients with Obesity and Metabolic Syndrome

Autor: Shigeo Kono, Akihiro Himeno, Taiichiro Okajima, Yasuhisa Kato, Rika Araki, Kazuhiko Kotani, Mariko Oishi, Akira Sugawara, Noriko Satoh-Asahara, Masakazu Hattori, Takafumi Majima, Akira Shimatsu, Kazunori Koyama, Makito Tanabe, Takayoshi Suganami, Yoshihiro Ogawa
Rok vydání: 2011
Předmět:
Male
Epidemiology
urologic and male genital diseases
Critical Care and Intensive Care Medicine
Severity of Illness Index
Gastroenterology
Japan
Risk Factors
Medicine
Metabolic Syndrome
biology
Arteries
Middle Aged
Cardiovascular Diseases
Nephrology
Creatinine
Disease Progression
Female
Kidney Diseases
medicine.symptom
Glomerular Filtration Rate
medicine.medical_specialty
Renal function
Risk Assessment
Renal tubular dysfunction
Predictive Value of Tests
Internal medicine
Weight Loss
Albuminuria
Humans
Obesity
Cystatin C
Analysis of Variance
Transplantation
Chi-Square Distribution
business.industry
Weight change
Original Articles
medicine.disease
Elasticity
Cross-Sectional Studies
Endocrinology
Chronic Disease
Arterial stiffness
biology.protein
Metabolic syndrome
business
Risk Reduction Behavior
Biomarkers
Kidney disease
Zdroj: Clinical Journal of the American Society of Nephrology. 6:265-273
ISSN: 1555-9041
Popis: Obesity and metabolic syndrome (MS) increase the risk of cardiovascular disease (CVD), chronic kidney disease (CKD), and all-cause mortality. Serum cystatin C (S-CysC), a marker of GFR, has been shown to be associated with CVD and CKD. This study was designed to elucidate the association of urinary CysC (U-CysC), a marker of renal tubular dysfunction, with CVD and CKD risk factors in patients with obesity and MS.The U-CysC-creatinine ratio (UCCR) was examined in 343 Japanese obese outpatients enrolled in the multi-centered Japan Obesity and Metabolic Syndrome Study.UCCR was positively correlated with urine albumin-creatinine ratio (UACR) and S-CysC and negatively correlated with estimated GFR (eGFR). Among obese patients, UCCR was significantly higher in MS patients than in non-MS patients. UCCR had significant correlations with the number of components of MS and arterial stiffness, all of which are CVD predictors, similarly to UACR (P0.05). Interestingly, diet- and exercise-induced weight reduction for 3 months significantly decreased only UCCR among all of the renal markers examined (P0.01), in parallel with the decrease in BMI, HbA1c, and arterial stiffness, suggesting the beneficial effect of weight reduction on renal tubular dysfunction.This study demonstrates that UCCR is significantly associated with renal dysfunction, the severity of MS, arterial stiffness, and weight change in obese patients. The data of this study suggest that U-CysC could serve as a CVD and CKD risk factor in patients with obesity and MS.
Databáze: OpenAIRE
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