Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

Autor: Jochen Behrends, Gülsah Gabriel, Peter J. M. Openshaw, Claudia Stoeger, Isabel Ben-Batalla, Arne Düsedau, Vinicius Pinho dos Reis, Valerie Gailus-Durner, Susanne Krauss-Etschmann, Annette Gries, Lucas Scholl, Aicha Jeridi, Martin Hrabé de Angelis, Ali Önder Yildirim, Helmut Fuchs, Nilgün Tekin-Bubenheim, Karin Klingel, Nikolaus Berenbrok, Fiona J. Culley, Sonja Loges, Andreas Kloetgen, Tatjana Manuylova, Hanna Jania, Martin A. Wolff, Bianca E. Schneider, Nancy Mounogou Kouassi, Kerstin Walendy-Gnirß, Martin Zickler, Henning Jacobsen, Gundula Pilnitz-Stolze
Přispěvatelé: National Institute for Health Research, BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.
Rok vydání: 2021
Předmět:
Alveolar macrophages
PROMOTES
General Physics and Astronomy
medicine.disease_cause
Mice
Pregnancy
Influenza A virus
Lung
Pathogen
RISK
Multidisciplinary
food and beverages
Bacterial Infections
Multidisciplinary Sciences
LUNG-FUNCTION
Mucosal immunology
Science & Technology - Other Topics
Female
Pathogens
Offspring
Science
IMMUNE
Mothers
Heterologous
Virus-host interactions
Article
General Biochemistry
Genetics and Molecular Biology
Virus
Immune system
INFLAMMATION
Orthomyxoviridae Infections
Influenza
Human
Macrophages
Alveolar
medicine
Animals
Humans
EXPOSURE
Adverse effect
FETAL
Science & Technology
business.industry
fungi
DEPEND
Parturition
Immunological surveillance
General Chemistry
biochemical phenomena
metabolism
and nutrition
medicine.disease
BIRTH-WEIGHT
Hematopoiesis
Mice
Inbred C57BL
Disease Models
Animal
Poly I-C
Animals
Newborn
Immunology
ASTHMA
business
Zdroj: Nature Communications
Nature communications
United Kingdom
England
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nat. Commun. 12:4957 (2021)
ISSN: 2041-1723
DOI: 10.1038/s41467-021-25220-3
Popis: Influenza during pregnancy can affect the health of offspring in later life, among which neurocognitive disorders are among the best described. Here, we investigate whether maternal influenza infection has adverse effects on immune responses in offspring. We establish a two-hit mouse model to study the effect of maternal influenza A virus infection (first hit) on vulnerability of offspring to heterologous infections (second hit) in later life. Offspring born to influenza A virus infected mothers are stunted in growth and more vulnerable to heterologous infections (influenza B virus and MRSA) than those born to PBS- or poly(I:C)-treated mothers. Enhanced vulnerability to infection in neonates is associated with reduced haematopoetic development and immune responses. In particular, alveolar macrophages of offspring exposed to maternal influenza have reduced capacity to clear second hit pathogens. This impaired pathogen clearance is partially reversed by adoptive transfer of alveolar macrophages from healthy offspring born to uninfected dams. These findings suggest that maternal influenza infection may impair immune ontogeny and increase susceptibility to early life infections of offspring.
Influenza infection during pregnancy can affect health of offspring but it is not clear how this affects immune responses. Here the authors use a mouse model to show that influenza infection during pregnancy can increase susceptibility to secondary infection and alter immune cell function in offspring.
Databáze: OpenAIRE
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