Association of body composition with survival and inflammatory responses in patients with non-metastatic nasopharyngeal cancer
| Autor: | Shousheng Liu, Lei Wang, Chang Jiang, Chenxi Yin, Jinsheng Huang, Sha-Sha He, Liangping Xia, Lin Yang, Qiu-Xia Yang, Wei Fan, Yanan Jin, Bei Zhang, Guifang Guo, Wenzhuo He, Xiao-ping Lin, Yu-Qing Liang, Yuming Rong, Wan-Ming Hu, Huijuan Qiu, Li-Li Liu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adipose tissue Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Clinical endpoint Non metastatic Humans In patient 030223 otorhinolaryngology Nasopharyngeal cancer business.industry nutritional and metabolic diseases Nasopharyngeal Neoplasms Middle Aged medicine.disease Survival Analysis Oncology Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Sarcopenia Cohort Body Composition Female Oral Surgery business human activities |
| Zdroj: | Oral oncology. 108 |
| ISSN: | 1879-0593 |
| Popis: | It is unknown whether or not the body composition is correlated with the prognosis and inflammatory response in patients with nasopharyngeal cancer (NPC).This cohort included 1767 patients with NPC. Visceral, subcutaneous and intra muscular adipose tissues (VAT, SAT and IMAT), and skeletal muscle index were quantified with computed tomography. We used the optimal stratification to select cut points for VAT, SAT and IMAT. We defined sarcopenia according to a widely used cut-point. The primary endpoint was overall survival (OS). The association between body composition and inflammatory response was also examined.Low VAT, SAT, IMAT and sarcopenia were observed in 260 (14.7%), 451 (25.5%), 773 (43.7%) and 683 (38.7%) patients, respectively. Low VAT (P 0.001, hazard ratio [HR], 1.884; 95% confidence interval [CI], 1.436-2.473,) and SAT (P = 0.022, HR, 1.334, 95%CI, 1.043-1.706) were both associated worse survival. IMAT and sarcopenia were not with prognostic value. In multivariate analysis, we found the prognostic value of the VAT (HR: 1.544, 95% CI: 1.128-2.114; P = 0.007) was independent of T stage, N stage, disease stage, lactic dehydrogenase, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), the systemic immune-inflammation index (SII), EBV-DNA and body mass index. We observed higher NLR (P = 0.028) and PLR (P 0.001) in patients with low SAT. Both low VAT (P = 0.009) and SAT (P = 0.005) were associated with decreased stromal lymphocyte infiltrating intensity.Among body composition parameters, VAT was an independent prognostic factor, especially in patients with locally advanced NPC. |
| Databáze: | OpenAIRE |
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