IFNG +874 A/T is associated with acute lymphoblastic leukemia in Mexican Mestizos
| Autor: | Brenda Lizeth Acosta-Maldonado, Betsy A. González-Quezada, Luis Manuel Valero-Saldaña, Hilario Flores-Aguilar, Clara Gorodezky, Roberto Ovilla-Martínez, Martín Pérez-García, Alberto Olaya-Vargas, Haydeé Salazar-Rosales |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Cellular immunity Adolescent Genotype medicine.medical_treatment Immunology Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Biochemistry Interferon-gamma Young Adult 03 medical and health sciences 0302 clinical medicine Gene Frequency Ethnicity medicine Humans Immunology and Allergy SNP Genetic Predisposition to Disease Allele Child Mexico Molecular Biology Alleles Aged Homozygote Infant Cancer Hematology Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Leukemia 030104 developmental biology Cytokine Case-Control Studies Child Preschool 030220 oncology & carcinogenesis Female |
| Zdroj: | Cytokine. 111:265-271 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2018.08.014 |
| Popis: | Acute lymphoblastic leukemia (ALL), the most common type of cancer in children worldwide, has one of the highest incidence rates in Mexico. It is a multifactorial disease and different cytokine single nucleotide polymorphisms (SNP), have been associated with ALL expression. Few studies have been published analyzing IFNG +874 T/A and IL2 −330 G/T in this type of leukemia. These SNPs are involved in high or low expression, and are central to cellular immunity, influencing greatly tumor growth. The purpose of this work was to explore the association of IFNG +874 A/T (rs2430561) and IL2 −330 G/T (rs2069762) SNPs with ALL susceptibility and/or protection in 488 Mexican Mestizos patients, as compared to 950 Mexican Mestizo healthy controls. The results demonstrated that IFNG +874 T allele (pc = 0.00004, OR = 0.673) and the TT genotype (pc = 0.00015, OR = 0.349), protect against ALL expression with no specific gender association; however, the TT homozygote genotype (vs. TA+AA) seems more protective in males (pc = 0.00683). IL2 −330 G/T does not contribute to the development of ALL. In healthy Mexicans, the most common genotypes for IL2 and IFNG, are the low cytokine producers, suggesting that the genetic background in this ethnic group, may be partly responsible for the high incidence of ALL. These results show for the first time in Mexicans, the relevant role that IFNG SNP has in the genetic etiology of ALL. Thus, a large group of patients belonging to different ethnicities will be very helpful to study in order to demonstrate if these SNPs contribute to the genetic etiology of ALL, as shown here in Mexican Mestizos. |
| Databáze: | OpenAIRE |
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