MAP2 immunoreactivity deficit is conserved across the cerebral cortex within individuals with schizophrenia
Autor: | Adam M. DeDionisio, RA DeGiosio, Kenneth N. Fish, David A. Lewis, Jason T. Newman, Robert A. Sweet, Allan R. Sampson, Ryan M. Kelly |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Postmortem studies lcsh:RC435-571 Biology Article 03 medical and health sciences 0302 clinical medicine lcsh:Psychiatry Lateral intraparietal cortex Internal medicine Quantitative fluorescence medicine 030304 developmental biology 0303 health sciences medicine.disease Cellular neuroscience Dorsolateral prefrontal cortex Psychiatry and Mental health medicine.anatomical_structure Visual cortex Endocrinology Cerebral cortex Schizophrenia Postmortem tissue 030217 neurology & neurosurgery |
Zdroj: | NPJ Schizophrenia npj Schizophrenia, Vol 5, Iss 1, Pp 1-9 (2019) |
ISSN: | 2334-265X |
Popis: | Several postmortem studies have reported lower levels of immunoreactivity (IR) for microtubule-associated protein 2 (MAP2) in several cortical regions of individuals with schizophrenia (SZ). However, whether this effect is conserved across multiple brain areas within an individual with SZ or if it is regionally-specific remains unclear. We characterized patterns of MAP2-IR across three cortical regions at different levels of the rostral-caudal axis within individual subjects with and without SZ. MAP2-IR levels were measured in deep layer 3 of dorsolateral prefrontal cortex (DLPFC), lateral intraparietal cortex (LIP), and primary visual cortex (V1). Postmortem tissue containing each cortical region was derived from 20 pairs of SZ subjects and nonpsychiatric comparison (NPC) subjects matched perfectly for sex, and as closely as possible for age and postmortem interval. MAP2-IR was assessed by quantitative fluorescence microscopy. We observed significantly lower levels of MAP2-IR in SZ subjects relative to NPC subjects, without a significant region by diagnosis interaction. Logs of the within-pair ratios (SZ:NPC) of MAP2-IR were significantly correlated across the three regions. These findings demonstrate that MAP2-IR deficits in SZ are consistent across three neocortical regions within individual subjects. This pattern of MAP2-IR deficit has implications for therapeutic development and future investigations of MAP2 pathology in SZ. |
Databáze: | OpenAIRE |
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