Epithelial–Mesenchymal Transition in Non Small-cell Lung Cancer

Autor: Eugene Dana, Evangelos Tsiambas, Nikolaos Salemis, Nikolaos Tsoukalas, Maria Tolia, Constantinos Giaginis, Athanasios Korogiannos, Eleni Aravantinou-Fatorou, Maria Kiakou, Stamatios Theocharis, George Kyrgias, Ioannis D. Kostakis, Andreas Karameris, Michail Galanopoulos, Ioannis Vamvakaris
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
Cancer Research
Pathology
medicine.medical_specialty
Epithelial-Mesenchymal Transition
Lung Neoplasms
non-small cell lung cancer (NSCLC)
Vimentin
Adenocarcinoma
Immunoenzyme Techniques
03 medical and health sciences
0302 clinical medicine
Antigens
CD
Carcinoma
Non-Small-Cell Lung
Biomarkers
Tumor
medicine
Humans
Neoplasm Invasiveness
Epithelial–mesenchymal transition
Lung cancer
Aged
Neoplasm Staging
Aged
80 and over
Tissue microarray
biology
Mesenchymal stem cell
Cancer
General Medicine
Middle Aged
Cadherins
Prognosis
medicine.disease
Fibronectins
Survival Rate
030104 developmental biology
Oncology
Tissue Array Analysis
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
biology.protein
Carcinoma
Large Cell
Immunohistochemistry
Female
Follow-Up Studies
Zdroj: Anticancer Research. 37:1773-1778
ISSN: 1791-7530
0250-7005
DOI: 10.21873/anticanres.11510
Popis: Background/aim Lung cancer is the first cause of cancer related deaths in both males and females. Epithelial-mesenchymal transition (EMT) is a reversible process by which epithelial cells transform to mesenchymal stem cells by losing their cell polarity and cell-to-cell adhesion, gaining migratory and invasive properties. High levels of E-cadherin are expressed in epithelial cells, whereas mesenchymal cells express high levels of N-cadherin, fibronectin and vimentin. The aim of this study was to evaluate the correlation between E-cadherin and vimentin expression and their clinical significance in non-small cell lung cancer (NSCLC). Materials and methods The immunohistochemical expression of E-cadherin, vimentin and Ki-67 was performed on tissue microarrays from NSCLC specimens obtained from 112 newly- diagnosed cases and were studied using classical pathological evaluation. Associations between E-cadherin, vimentin and Ki-67 expression, clinicopathological variables and survival were analyzed. In all cases, a value of p≤0.05 was considered significant. Results Low E-cadherin expression was significantly correlated with tumor necrosis (p=0.019). Moreover, there was a trend for correlation between high E-cadherin expression and better overall survival (hazard ratio=1.02, and 95% confidence interval=0.45-1.87, p=0.091). There was also a significant negative correlation between vimentin expression and overall survival (hazard ratio=1.13, and 95% confidence interval=0.78-1.65, p=0.026). Additionally, there was a significant negative correlation between vimentin expression and grade I tumors (p=0.031). Finally, a positive correlation trend between vimentin expression and Ki-67 was found (p=0.073). Conclusion High E-cadherin and low vimentin expression correlate with better prognosis and overall survival.
Databáze: OpenAIRE
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