Modified spectrometry (O2C device) of intraoperative microperfusion predicts organ function after kidney transplantation: a pilot study
| Autor: | Stefan Hauser, S.C. Müller, Guido Fechner, O. Luzar, J. von Pezold, R.H. Tolba |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Graft Rejection medicine.medical_specialty medicine.medical_treatment Urinary system Urinary Bladder Urology Blood Pressure Hepatic Veins Hepatic Artery Postoperative Complications Predictive Value of Tests Monitoring Intraoperative medicine Cadaver Humans Transplantation Homologous Kidney transplantation Dialysis Retrospective Studies Transplantation Kidney Hematoma business.industry Middle Aged medicine.disease Kidney Transplantation Tissue Donors Surgery Perfusion Blood pressure medicine.anatomical_structure Stents Hemoglobin Ureter business |
| Zdroj: | Transplantation proceedings. 41(9) |
| ISSN: | 1873-2623 |
| Popis: | Background Delayed graft function (DGF) is defined as posttransplantation dialysis within 1 week, which might be associated with impaired long-term graft survival. The aim of our pilot study was to establish the ability of intraoperative spectrometry of allograft microperfusion to predict DGF. Methods Twenty human kidney allografts transplanted from deceased donors were evaluated intraoperatively after reperfusion using modified organ spectrometry (O2C device). We examined hemoglobin oxygen saturation, intravascular amount of hemoglobin, and microperfusion flow/velocity. Results Retrospectively, 10/20 (50%) allografts with measurable impairment of cortical hemoglobin oxygen saturation and microperfusion flow/velocity developed DGF. Retrospectively, we found that if the intravascular amount of hemoglobin was increased upon intraoperative measurement, the kidney was prone to develop DGF. Conclusions Spectrometry data predicted DGF. Our results supported the thesis that impaired microperfusion is the key to DGF and might be related to postcapillary endothelial damage or intravascular sludge. |
| Databáze: | OpenAIRE |
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