Association of Melatonin Pathway Gene's Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population

Autor: Xiao-Mei Li, Yan-Mei Mao, De-Guang Wang, Lei Liu, Qian Wu, Hai-Feng Pan, Peng Wang, Li-Fang Zhao, Chan-Na Zhao, Yi-Lin Dan
Rok vydání: 2019
Předmět:
0301 basic medicine
lcsh:Immunologic diseases. Allergy
Adult
Male
Article Subject
Immunology
Gene Expression
Single-nucleotide polymorphism
Arylalkylamine N-Acetyltransferase
Polymorphism
Single Nucleotide
03 medical and health sciences
0302 clinical medicine
Asian People
Gene Frequency
Polymorphism (computer science)
medicine
Immunology and Allergy
Humans
Lupus Erythematosus
Systemic
Genetic Predisposition to Disease
skin and connective tissue diseases
Allele frequency
Genetic Association Studies
Genetic association
Melatonin
030203 arthritis & rheumatology
Lupus erythematosus
business.industry
Receptor
Melatonin
MT2
Receptor
Melatonin
MT1
Haplotype
Case-control study
General Medicine
Middle Aged
medicine.disease
030104 developmental biology
Haplotypes
Case-Control Studies
Female
medicine.symptom
business
Malar rash
lcsh:RC581-607
Research Article
Zdroj: Journal of Immunology Research
Journal of Immunology Research, Vol 2019 (2019)
ISSN: 2314-7156
Popis: Objectives. This study was to investigate the association of melatonin (MTN) pathway gene’s single-nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE). Methods. We recruited 495 SLE patients and 493 healthy controls, 11 tag SNPs in MTN receptor 1a (MTNR1a), MTNR1b, and arylalkylamine N-acetyltransferase (AANAT) genes were genotyped and analyzed. Serum MTN concentration was determined by enzyme-linked immunosorbent assay (ELISA) kits. Results. Two SNPs of AANAT gene (rs8150 and rs3760138) associated with the risk of SLE; CC carriers of rs8150 had a lower risk as compared to GG (OR=0.537, 95% CI: 0.361, 0.799), whereas GG carrier in rs3760138 had an increased risk (OR=1.823, 95% CI: 1.154, 2.880) compared to TT. However, we did not find any genetic association between the other nine SNPs with SLE risk. Case-only analysis showed associations of rs2165667 and rs1562444 with arthritis, rs10830962 with malar rash, rs3760138 with immunological abnormality, and rs8150 with hematological abnormality. Furthermore, a significant difference between plasma MTN levels with different genotypes of rs1562444 was observed. Haplotype analyses revealed that haplotype of CCTAT, CTAGT, and GGG was significantly associated with the increased risk in SLE susceptibility, but TCTAT and CTG appeared to be a protective haplotype. Conclusions. The present study supported the genetic association of MTN pathway genes with SLE susceptibility and specific clinical manifestations, suggesting the potential role of MTN pathway genes in the pathogenesis and development of SLE.
Databáze: OpenAIRE
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