Sodium nitroprusside enhanced cardiopulmonary resuscitation (SNPeCPR) improves vital organ perfusion pressures and carotid blood flow in a porcine model of cardiac arrest
| Autor: | James Kolbeck, Scott McKnite, Jason C. Schultz, Nicolas Segal, Emily Caldwell, Demetris Yannopoulos |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Nitroprusside
medicine.medical_specialty Swine medicine.medical_treatment Vasodilator Agents Vasodilation Emergency Nursing Return of spontaneous circulation Article Random Allocation Internal medicine Medicine Animals Cardiopulmonary resuscitation Vital organ Analysis of Variance business.industry Hemodynamics Blood flow Cardiopulmonary Resuscitation Heart Arrest Disease Models Animal Carotid Arteries Regional Blood Flow Anesthesia cardiovascular system Emergency Medicine Cardiology Female Sodium nitroprusside Cardiology and Cardiovascular Medicine business Perfusion Blood Flow Velocity medicine.drug |
| Zdroj: | Resuscitation. 83(3) |
| ISSN: | 1873-1570 |
| Popis: | To describe a new method of CPR that optimizes vital organ perfusion pressures and carotid blood flow. We tested the hypothesis that a combination of high dose sodium nitroprusside (SNP) as well as non-invasive devices and techniques known independently to enhance circulation would significantly improve carotid blood flow (CBF) and return of spontaneous circulation (ROSC) rates in a porcine model of cardiac arrest.15 isofluorane anesthetized pigs (30±1 kg), after 6 min of untreated ventricular fibrillation, were subsequently randomized to receive either 15 min of standard CPR (S-CPR) (8 animals) or 5 min epochs of S-CPR followed by active compression-decompression (ACD)+inspiratory impedance threshold device (ITD) CPR followed by ACD+ITD+abdominal binding (AB) with 1mg of SNP administered at minutes 2, 7, 12 of CPR (7 animals). Primary endpoints were CBF and ROSC rates. ANOVA and Fisher's exact test were used for comparisons.There was significant improvement in the hemodynamic parameters in the SNP animals. ROSC was achieved in 7/7 animals that received SNP and in 2/8 in the S-CPR (p=0.007). CBF and end tidal CO(2) (ETCO(2)) were significantly higher in the ACD+ITD+AB+SNP (SNPeCPR) animals during CPR. Bolus doses of SNP, when used in conjunction with ACD+ITD+AB CPR, significantly improve CBF and ROSC rates compared to S-CPR. |
| Databáze: | OpenAIRE |
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