Effect of Ivacaftor on Objective and Subjective Measures of Cough in Patients with Cystic Fibrosis
| Autor: | Dejene Shiferaw, Alyn H. Morice, Shoaib Faruqi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry medicine.medical_specialty Cystic fibrosis Gastroenterology Article Ivacaftor Efficacy 03 medical and health sciences 0302 clinical medicine G551D mutation Internal medicine medicine 030212 general & internal medicine Lung function medicine.diagnostic_test business.industry Reflux Objective Improvement medicine.disease respiratory tract diseases Cough 030228 respiratory system business Airway Gastro-oesophageal reflux medicine.drug |
| Zdroj: | The Open Respiratory Medicine Journal |
| ISSN: | 1874-3064 |
| Popis: | Background and Objectives: Cough is a major symptom in cystic fibrosis. Ivacaftor is a novel drug which targets the G551D mutation and has been demonstrated to improve lung function and weight in the long term. It also improves symptoms of extra-oesophageal reflux. We wanted to evaluate the effect of ivacaftor on cough in cystic fibrosis. Methods: In two patients with cystic fibrosis the Hull Airway Reflux Questionnaire (HARQ) was completed and objective cough counts were measured prior to and within 4 weeks after initiation of treatment with ivacaftor. Spirometry was also undertaken and weight checked at these time frames. Results: In the first patient the HARQ score decreased from 29 to 11 and objective cough counts from 29 to 9 cough events per hour. Similarly in the second patient the HARQ score decreased from 13 to 9 and objective cough count from 76 to 5 cough events per hour. There was no significant change in spirometric parameters or weight. Conclusion: We have observed early subjective and objective improvement in cough measures on treatment with ivacaftor. We suggest that this improvement could be attributed to improvement of gastro-intestinal function and that cough metrics could be used as early and accurate end points of drug efficacy. |
| Databáze: | OpenAIRE |
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