High dietary glycemic load is associated with higher concentrations of urinary advanced glycation endproducts

Autor: Casper G. Schalkwijk, Kim Maasen, Jean L.J.M. Scheijen, Marleen M.J. van Greevenbroek, Coen D.A. Stehouwer, Carla J.H. van der Kallen
Přispěvatelé: Promovendi CD, RS: CARIM - R3 - Vascular biology, Interne Geneeskunde, MUMC+: MA Alg Onderzoek Interne Geneeskunde (9), RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Glycation End Products
Advanced
Male
0301 basic medicine
Medicine (miscellaneous)
Urine
Type 2 diabetes
Cohort Studies
chemistry.chemical_compound
0302 clinical medicine
Glycation
INDEX
INSULIN-RESISTANCE
Nutrition and Dietetics
Methylglyoxal
DICARBONYL STRESS
Middle Aged
Glycemic index
nutrition
CARDIOVASCULAR-DISEASE
glycotoxin
Female
type 2 diabetes
advanced glycation endproducts
medicine.medical_specialty
END-PRODUCTS
cardiovascular complications
CANCER-RISK
030209 endocrinology & metabolism
03 medical and health sciences
AGE
INFLAMMATION
FOOD
Internal medicine
Diabetes mellitus
Glycemic load
glycemic load
Dietary Carbohydrates
medicine
Humans
Pentosidine
PLASMA-LEVELS
Aged
dicarbonyls
business.industry
medicine.disease
Cross-Sectional Studies
030104 developmental biology
Endocrinology
chemistry
glycation
glycemic index
business
diet
Zdroj: American Journal of Clinical Nutrition, 110(2), 358-366. Oxford University Press
ISSN: 0002-9165
DOI: 10.1093/ajcn/nqz119
Popis: Background: Advanced glycation endproducts (AGEs) and their precursors (dicarbonyls) are associated with the progression of diseases such as diabetes and cardiovascular disease. Plasma concentrations of dicarbonyls methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) are increased after an oral glucose load indicating that consumption of diets high in carbo hydrates may induce the endogenous formation of dicarbonyls and AGEs.Objective: To examine the associations of dietary glycemic index (GI) and glycemic load (GL) with concentrations of dicarbonyls and AGEs in plasma and urine.Methods: Cross-sectional analyses were performed in a human observational cohort [Cohort on Diabetes and Atherosclerosis Maastricht (CODAM), n = 494, 59 +/- 7 y, 25% type 2 diabetes]. GI and GL were derived from FFQs. Dicarbonyls and AGEs were measured in the fasting state by ultra-performance liquid chromatography-tandem MS. MGO, GO, and 3-DG and protein-bound N-epsilon-(carboxymethyl)lysine (CML), N-epsilon-(1-carboxyethyl)lysine (CEL), and pentosidine were measured in plasma. Free forms of CML, CEL, and N-delta-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were measured in both plasma and urine. Multiple linear regression was performed with dicarbonyls and AGEs as dependent variables, and dietary GI or GL as main independent variables (all standardized). Models were adjusted for health and lifestyle factors, dietary factors, and reciprocally for GI and GL. As this was an explorative study, we did not adjust for multiple testing.Results: GI was not associated with any of the dicarbonyls or AGEs. GL was positively associated with free urinary MG-H1 (beta = 0.34; 95% CI: 0.12, 0.55). Furthermore, GL was positively associated with free plasma MG-H1 and free urinary CML (beta = 0.23; 95% CI: 0.02, 0.43; and beta = 0.28; 95% CI: 0.06, 0.50), but these associations were not independent of dietary AGE intake.Conclusions: A habitual diet higher in GL is associated with higher concentrations of free urinary MG-H1. This urinary AGE is most likely a reflection of AGE accumulation and degradation in tissues, where they may be involved in tissue dysfunction.
Databáze: OpenAIRE
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