Arginine behaviour after arginine or citrulline administration in older subjects
| Autor: | Yves Boirie, Jean Maccario, Stéphane Walrand, J. Marc, Christophe Moinard, Luc Cynober, Virginie Lasserre |
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| Přispěvatelé: | Laboratoire de Biologie de la Nutrition EA 4466, Faculté des sciences pharmaceutiques et biologiques, Université Paris Descartes - Paris 5 (UPD5), Laboratoire de Biomathématiques et Biostatistiques, Faculté de Pharmacie, Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Service interhospitalier de Biochimie, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), French Ministry of Research and Technology EA 4466, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), CHU Cochin [AP-HP], Université Paris Descartes - Paris 5 ( UPD5 ), Unité de Nutrition Humaine - Clermont Auvergne ( UNH ), Université Clermont Auvergne ( UCA ) -Institut national de la recherche agronomique [Auvergne/Rhône-Alpes] ( INRA Auvergne/Rhône-Alpes ) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Ornithine medicine.medical_specialty Arginine [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition amino-acids Medicine (miscellaneous) Body Mass Index personne âgée 03 medical and health sciences chemistry.chemical_compound Pharmacokinetics In vivo Internal medicine Food supplements medicine Citrulline Humans Amino Acids senior citizens Aged Volume of distribution 030109 nutrition & dietetics Nutrition and Dietetics Fasting 3. Good health Bioavailability supplément alimentaire acide aminé Endocrinology chemistry Dietary Supplements Lean body mass pharmacokinetics [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition amino acid |
| Zdroj: | British Journal of Nutrition British Journal of Nutrition, Cambridge University Press (CUP), 2016, 115 (3), pp.399-404. ⟨10.1017/s0007114515004638⟩ British Journal of Nutrition, Cambridge University Press (CUP), 2016, 115 (3), pp.399-404. 〈10.1017/s0007114515004638〉 |
| ISSN: | 0007-1145 1475-2662 |
| DOI: | 10.1017/s0007114515004638⟩ |
| Popis: | Arginine (ARG) and its precursor citrulline (CIT) are popular dietary supplements, especially for the elderly. However, age-related reductions in lean body mass and alterations in organ functions could change their bioavailability. Pharmacokinetics and tolerance to amino acid (AA) loads are poorly documented in elderly subjects. The objective here was to characterise the plasma kinetics of CIT and ARG in a single-dosing study design. Eight fasting elderly men underwent two separate isomolar oral loading tests (10 g of CIT or 9·94 g of ARG). Blood was withdrawn over an 8-h period to measure plasma AA concentrations. Only CIT, ornithine and ARG plasma concentrations were changed. Volume of distribution was not dependent on AA administered. Conversely, parameters related to ARG kinetics were strongly dependent on AA administered: after ARG load, elimination was higher (ARG>CIT; P=0·041) and admission period+time at peak concentration was lower (ARGP=0·033), and the combination of both phenomena results in a marked increase in ARG availability when CIT was administered (ARGP=0·033) compared with ARG administration itself. In conclusion, a single CIT administration in the elderly is safe and well tolerated, and CIT proves to be a better in vivo ARG precursor than ARG itself in healthy elderly subjects. |
| Databáze: | OpenAIRE |
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