The role of potassium channels on vasorelaxant effects of elabela in rat thoracic aorta
| Autor: | Serdar, Şahintürk, Naciye, İşbil |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Turkish Journal of Thoracic and Cardiovascular Surgery. 30:18-25 |
| ISSN: | 2149-8156 1301-5680 |
| DOI: | 10.5606/tgkdc.dergisi.2022.22756 |
| Popis: | Background:This study aims to investigate the roles of potassium channel subtypes in the vasorelaxant effect mechanism of elabela, which is a recently discovered endogenous apelin receptor ligand.Methods:The vascular rings (4-mm) obtained from the thoracic aortas of 20 male Wistar Albino rats were placed into the isolated tissue bath system. The resting tension was set to 1 g. The aortic rings were contracted with 10-5 molar phenylephrine after the equilibration period (90 min). Elabela was applied cumulatively (10-10-10-6 molar) to the aortic rings in the plateau phase. The experimental protocol was repeated in the presence of specific potassium channel subtype inhibitors to determine the role of potassium channels in the vasorelaxant effect mechanism of elabela.Results:Elabela induced a concentration-dependent vasorelaxation (pConclusion:Our results suggest that large-conductance calciumactivated, voltage-gated, adenosine triphosphate-sensitive, and inward-rectifier potassium channels are involved in the vasorelaxant effect mechanism of elabela in the rat thoracic aorta. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|