The localization and concentration of copper in the fallopian tube in women with or without an intrauterine contraceptive device
| Autor: | Nils-Petter Berg Justesen, Arne Skare, Roar Sandvei, Anne-Lone Wollen |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty Statistical difference chemistry.chemical_element Andrology Pregnancy User group Medicine Humans Fallopian Tubes Gynecology Mucous Membrane biology business.industry Genitourinary system Histocytochemistry Obstetrics and Gynecology Ceruloplasmin Histology General Medicine Copper medicine.anatomical_structure chemistry biology.protein Female Uterine cavity business Fallopian tube Intrauterine Devices |
| Zdroj: | Acta obstetricia et gynecologica Scandinavica. 73(3) |
| ISSN: | 0001-6349 |
| Popis: | The localization and concentration of copper in cryostat sections of human fallopian tubes from women using an intrauterine contraceptive device (IUCD) and controls was determined by light microscopic- and atomic absorption spectrophotometric techniques. The copper was visually accumulated in the epithelium and the copper concentration in the tubal tissue was increased in the IUCD user group. We also measured the concentration of copper and ceruloplasmin in serum, but there was no statistical difference between the two groups studied. Our results indicate that the IUCD has effects beyond the uterine cavity. The accumulation of copper may be associated with earlier observations of the morphological changes and infiltration of inflammatory cells observed in the fallopian tube in IUCD users.During laparoscopic sterilization at a hospital in Bergen, Norway, surgeons removed a 1 cm segment of the macroscopic isthmic portion of the fallopian tube from 40 healthy, nonpregnant women. They used light microscopic and atomic absorption spectrophometric techniques to localize and measure the concentration of copper in cryostat sections of the fallopian tubes of 20 women who had used a copper releasing IUD for more than six months and of 20 other women who used neither an IUD nor an hormonal contraceptive. Copper was visually present in the epithelium, but weakly so, in few of the biopsies from the non-IUD users. In IUD users, it accumulated throughout the epithelium and dwindled in the lamina propria. Its mean concentration in the fallopian tube was 58% higher in IUD users than non-IUD users (128.3 vs. 81.4 nmol/mg protein; p = 0.003). IUD use did not affect protein levels. The IUD affected neither the concentration of copper nor of the copper-transporting protein, ceruloplasmin, in serum. These findings suggest that the accumulation of copper in the fallopian tube in IUD users may effect morphological changes and infiltration of inflammatory cells in the fallopian tube. |
| Databáze: | OpenAIRE |
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