Delivery of plant-made vaccines and therapeutics

Autor:	Amanda Maree Walmsley, Assunta Pelosi, Robert Shepherd
Rok vydání:	2012
Předmět:	Clinical Trials as Topic Vaccines Vaccination Administration Oral Bioengineering Plants Genetically Modified Applied Microbiology and Biotechnology Drug Delivery Systems Adjuvants Immunologic Risk analysis (engineering) Models Animal Immunology Animals Humans Business Immunity Mucosal Biotechnology
Zdroj:	Biotechnology Advances. 30:440-448
ISSN:	0734-9750
DOI:	10.1016/j.biotechadv.2011.07.018
Popis:	As commercial approval of the first, purified, plant-based biopharmaceuticals for parenteral delivery to humans approaches, improved strategies for delivery of plant-made vaccines and therapeutics are required to ensure their further development and to fulfil the prospect of supplying a global solution for affordable medicines. To ensure that this occurs, research should investigate and characterise the host immune system in addition to the effects of adjuvants and carrier vehicles on consistency and efficacy of vaccination. In this review we explore the basic understandings of pharmaceutical delivery and its effect on immunogenicity in an effort to advance the plant-made pharmaceutical platform.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42125f94c6c96cc0ac4b0eaff4f7a1f0 https://doi.org/10.1016/j.biotechadv.2011.07.018 Zobrazit plný text záznamu Full Text from ScienceDirect