Acceleration of DNA synthesis in post-hepatectomized regenerating liver of normal rat by insulin and glucagon
| Autor: | Akira Sakuma, Shunji Mishiro, Toshitsugu Oda, Katsuyoshi Takatsuki, Shigeki Hayashi, Yasuhiko Ota, Kenji Fujiwara, Hiroshi Oka, Masao Torii, Itsuro Ogata |
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| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Biology Tritium Glucagon General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Animals Hepatectomy Insulin General Pharmacology Toxicology and Pharmaceutics DNA synthesis Significant difference Rats Inbred Strains DNA General Medicine Liver regeneration Liver Regeneration Rats Kinetics Endocrinology Liver chemistry Thymidine Hormone |
| Zdroj: | Life Sciences. 29:2609-2615 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(81)90634-2 |
| Popis: | The effect of insulin and/or glucagon on the cumulative incorporation of tritiated thymidine was studied using normal rats with post-hepatectomized regenerating livers. Although the cumulative incorporation value was low at 20 hr and increased thereafter, a significant difference was not found between control and treated rats up to 60 hr after the operation. However, when rats were distributed according to the time the incorporation reached a maximum, there was a significant difference in the distributions between control rats and rats treated with combined insulin and glucagon (P=0.0303); more rats showed maximum incorporation at earlier times after treatment. These results suggest that a combination of the two hormones accelerates DNA synthesis in post-hepatectomized regenerating liver of normal rats. |
| Databáze: | OpenAIRE |
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