Ocular manifestations of leukemia: leukemic infiltration versus infectious process
| Autor: | Alexander R. Irvine, Joan M. O'Brien, Edward L. Howes, Hope S. Rugo, Susan R. Carter, Kathleen B. Gordon, Jacque L. Duncan |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Myeloid Retina Diagnosis Differential chemistry.chemical_compound Myelogenous Retinal Diseases Leukemic Infiltration Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Child Retrospective Studies business.industry Medical record Retinal Retrospective cohort study Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Dermatology Combined Modality Therapy Magnetic Resonance Imaging Ophthalmology Leukemia Leukemia Myeloid Acute medicine.anatomical_structure chemistry Female business Retinopathy |
| Zdroj: | Ophthalmology. 108(12) |
| ISSN: | 0161-6420 |
| Popis: | Objective To determine whether specific guidelines can be developed to distinguish whether retinal infiltration in leukemia patients represents infection or neoplasia. Design Retrospective noncomparative interventional case series. Participants Six patients recently seen at University of California San Francisco with retinal infiltrates in a setting of leukemia, for which adequate written and photographic information of disease course was available. Intervention Observation consisted of retrospective review of clinic charts, hospital medical records, and fundus photographs. Main outcome measures Determination of whether retinal infiltrates represented neoplasia or infection was made by review of medical records. Results In this series, neoplastic retinal infiltrates were found in patients who had newly diagnosed leukemia and those who were in blast crisis. In contrast, the two patients who were in complete remission, but had undergone bone marrow transplantation, had retinal infiltrates attributable to infection. Conclusions Every patient with retinal infiltrates in the setting of newly or previously diagnosed leukemia requires a systemic and central nervous system workup before the initiation of ophthalmologic treatment. The systemic status of the patient is highly informative in determining whether infection or neoplasia is responsible for the infiltration. |
| Databáze: | OpenAIRE |
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