| Autor: |
Thanh-Sang Vo, Huu-Hung Nguyen, Thi-Phuong Nguyen, Thi-Minh-Dinh Tran, Xuan-Hao Bui, Minh-Hiep Dinh, Nguyen-Kim-Tuyen Pham, Jirapast Sichaem, Van-Son Dang, Ngoc-Hong Nguyen, Thuc-Huy Duong |
| Rok vydání: |
2022 |
| Předmět: |
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| DOI: |
10.6084/m9.figshare.19248196.v1 |
| Popis: |
Two new cycloartanes, combretic acid C (1) and combretanone I (3), were isolated from the leaves of Combretum quadrangulare Kurz, together with the previously-reported combretic acids A-B (2 and 5) and combretanone A (4). An extensive set of spectroscopic methods were used to elucidate the structures of these compounds. Cytotoxicity against the K562 cancer cell line was evaluated. Compound 1 showed strong activity, with an IC50 value of 9.7 µM. The other compounds showed moderate activity. Alpha-glucosidase inhibition was also evaluated. The isolated compounds showed moderate inhibition, with IC50 values in the range 102.2-194.7 µM. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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