Plasma protein C as a marker of hepatocellular damage in alcoholic liver disease
| Autor: | M. Mian, Kłoczko J, Bielawiec M, L. Babiuch, Marek Z. Wojtukiewicz, Marzenna Galar |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
medicine.medical_specialty Alcoholic liver disease Liver Cirrhosis Alcoholic Physiology (medical) Internal medicine medicine Cholinesterases Humans Aspartate Aminotransferases Liver Diseases Alcoholic Clotting factor Prothrombin time Hepatitis medicine.diagnostic_test business.industry Hepatitis Alcoholic Antithrombin Fatty liver Alanine Transaminase Hematology gamma-Glutamyltransferase Middle Aged medicine.disease Alkaline Phosphatase Blood proteins Blood Coagulation Factors Endocrinology medicine.anatomical_structure Hepatocyte Prothrombin business Biomarkers medicine.drug Fatty Liver Alcoholic Protein C |
| Zdroj: | Haemostasis. 22(6) |
| ISSN: | 0301-0147 |
| Popis: | The synthesis of a number of clotting factors takes place in a hepatocyte. Therefore, measurement of these factors in the blood have proved to be of additional value in the diagnosis and follow-up of liver diseases. In the present study we evaluated protein C level in the plasma of patients with liver cell damage due to chronic alcohol consumption. A decrease in plasma protein C concentration which correlated with clinical performance of the patients was found. Significant correlations between the level of protein C and antithrombin III, one-stage prothrombin time, factors VII and X and some biochemical tests reflecting liver cell damage were also stated. The obtained data indicate that plasma protein C level may constitute a useful marker of hepatocellular disease in alcoholics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|