Evaluating the role of 1.5 T quantitative susceptibility mapping for subthalamic nucleus targeting in deep brain stimulation surgery
| Autor: | Ileana Hancu, Tanweer Rashid, Marisa DiMarzio, Julie G. Pilitsis, Roy Hwang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Deep brain stimulation
Deep Brain Stimulation medicine.medical_treatment Anatomical structures 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Radial error Subthalamic Nucleus medicine Humans Radiology Nuclear Medicine and imaging Brain Mapping Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Parkinson Disease Magnetic resonance imaging Quantitative susceptibility mapping Magnetic Resonance Imaging Electrodes Implanted Subthalamic nucleus surgical procedures operative nervous system Neurology (clinical) Nuclear medicine business 030217 neurology & neurosurgery Deep brain stimulation surgery Gradient echo |
| Zdroj: | Journal of Neuroradiology. 48:37-42 |
| ISSN: | 0150-9861 |
| Popis: | Background and purpose Quantitative susceptibility mapping (QSM) has been shown to be valuable in direct targeting for subthalamic nucleus (STN) DBS, given its higher quality of contrast between the STN border and adjacent anatomical structures. The objective is to demonstrate the feasibility of using 1.5 T QSM for direct targeting in STN DBS planning. Material and methods Eleven patients underwent MRI acquisitions using a 1.5 T scanner, including multi-echo gradient echo sequences for generating QSM images. 22 STN targets were planned with direct targeting method using QSM images by one stereotactic neurosurgeon and indirect targeting method using standard protocol by a second stereotactic neurosurgeon. The two physicians were blinded to each other's results. Results The mean coordinates for the STN using direct targeting relative to the mid-commissural point (MCP) was 11.41 ± 2.43 mm lateral, 2.48 ± 0.53 mm posterior and 4.45 ± 0.95 mm inferior. The mean coordinates for the STN using indirect targeting was 11.79 ± 2.51 mm lateral, 2.55 ± 0.54 mm posterior, and 4.84 ± 1.03 mm inferior. The mean (±SEM) radial error between the direct and indirect target was 0.67 ± 0.14 mm. In cases where DBS electrodes were implanted, the radial difference between the indirect and actual target (1.19 ± 0.30 mm) was statistically equivalent to the radial difference between the direct and actual target (1.0 ± 0.27 mm). Conclusions Direct targeting of the STN for DBS implantation using 1.5 T QSM was found to be statistically equivalent to standard protocol surgery planning. This may offer a simpler, more intuitive alternative for DBS surgery planning at centers with 1.5 T MRIs. |
| Databáze: | OpenAIRE |
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