Oxidation of meso-Diaminosuccinic Acid, a Possible Natural Substrate for d-Aspartate Oxidase
| Autor: | Augusto Rinaldi, Carlo Crifò, Mariagiuseppina Pellegrini, Carlo De Marco |
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| Rok vydání: | 2005 |
| Předmět: |
D-aspartate oxidase
chemistry.chemical_classification Aspartic Acid D-Aspartate Oxidase Oxidase test Chemistry Decarboxylation Deamination Amino Acids Diamino Substrate (chemistry) Oxidative deamination Kidney Biochemistry Medicinal chemistry Substrate Specificity Amino acid Kinetics Oxygen Consumption Spectrophotometry Aspartic acid Animals Organic chemistry Cattle Amino Acid Oxidoreductases Oxidation-Reduction |
| Zdroj: | European Journal of Biochemistry. 117:635-638 |
| ISSN: | 1432-1033 0014-2956 |
| DOI: | 10.1111/j.1432-1033.1981.tb06385.x |
| Popis: | meso-Diaminosuccinic acid, a natural antagonist of aspartic acid, is a good substrate for beef kidney D-aspartate oxidase. The oxygen consumption and the ammonia production are in good agreement with the stoichiometry of a typical oxidative deamination. The deamination involves only one of the two amino groups of diaminosuccinate, and is followed by decarboxylation of the first reaction product, 2-amino-3-oxosuccinic acid. By condensation of the compounds thus originating from this latter, pyrazine 2,5-dicarboxylic acid and pyrazine 2,6-dicarboxylic acid are formed. DL-Diaminosuccinic acid is not oxidized by D-aspartate oxidase, nor does it inhibit the enzyme activity. |
| Databáze: | OpenAIRE |
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