Brain 3D-echographic early predictors of neuro-behavioral disorders in infants: a prospective observational study
| Autor: | Antonella Barbati, Sandro Gerli, Natasha Nikolova, Maria Cristina Aisa, Benito Cappuccini, Giulia Babucci, Francesca De Rosa, Irene Giardina, Graziano Clerici |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Intrauterine growth restriction Gestational Age 03 medical and health sciences 0302 clinical medicine IUGR 030225 pediatrics thalamus medicine Humans reproductive and urinary physiology Fetal Growth Retardation business.industry abnormal neuro-development Infant Newborn Obstetrics and Gynecology Brain Infant medicine.disease female genital diseases and pregnancy complications Low birth weight 3D-echography Pediatrics Perinatology and Child Health cerebral volumes preterm Observational study medicine.symptom business Head 030217 neurology & neurosurgery Infant Premature |
| Popis: | Prematurity, low birth weight (LBW), very low birth weight (VLBW), and intrauterine growth restriction (IUGR) are risk factors of long-term poor neuro-development outcomes and associate with reduction of regional brain volumes.To evaluate the possible role of 3D ultrasound sonography (3DUS) regional brain volumes, measured at 30-40 days of postnatal period, as early predictors of long-term risk of neuro-behavioral disorders.A highly selected population, which included: full-term, preterm, IUGR, and preterm-IUGR born individuals, was followed longitudinally from 30 to 40 days of postnatal period to the second year of life. The population was mostly composed of bichorionic twins to ensure a, theoretically, major intracategory homogeneity. Preterm and IUGR subjects were characterized by a gestational age (GA) and birth weight (BW)32 weeks and1500 g, respectively, whereas the full-term neonates were of 37 weeks GA. At enrollment, the assessment of the volumetric measurements was performed using the 3DUS. The evaluation of neuro-development was performed at 2 years using the Griffiths Mental Development Scales.The 3DUS measurements of whole brain, thalamus, frontal cortex, and cerebellum volumes, assessed at 30-40 days of postnatal period, were significantly reduced in infants characterized by negative outcome. In addition, the respective areas of the ROC curves, made by comparing values of normal and abnormal neuro-development groups, were indicative of a strong diagnostic accuracy.Data found suggest that the 3DUS regional brain volumes may assume a significant role as early indicators of neonates at major risk of neuro-behavioral disorders in later life. Further and larger studies in this direction are needed to validate this significant perspective. |
| Databáze: | OpenAIRE |
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