Use of auditory brainstem responses for the early detection of ototoxicity from aminoglycosides or chemotherapeutic drugs
| Autor: | Roger M. Ellingson, Stephen A. Fausti, James A. Henry, Mitchell Cr |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Tone burst medicine.medical_specialty Hearing loss Early detection Antineoplastic Agents Audiology Ototoxicity otorhinolaryngologic diseases Evoked Potentials Auditory Brain Stem Medicine Humans Hearing change Hearing Loss High-Frequency business.industry Rehabilitation Reproducibility of Results Auditory Threshold medicine.disease Time efficient Audiometry Evoked Response Aminoglycosides Early Diagnosis Audiometry Pure-Tone Female sense organs Chemotherapeutic drugs Brainstem medicine.symptom business |
| Zdroj: | Journal of rehabilitation research and development. 41(3A) |
| ISSN: | 1938-1352 |
| Popis: | Effective objective HF (high-frequency) testing methodology provides for the early detection of ototoxic hearing loss because it typically progresses from high to low frequencies. Such early detection is considered necessary to prevent hearing loss from progressing into the frequency range important for understanding speech. Objective tests must be reliable, sensitive to hearing change, and time efficient. Auditory brainstem responses (ABRs) appear well suited to this task; however, current ABR techniques have limitations. Conventional clicks stimulate middle (1-4 kHz) rather than high frequencies (>8 kHz). Responses to HF tone bursts require considerable recording time. We hypothesized that using HF band-limited clicks (HF clicks) could overcome these limitations. Two different HF clicks, with bandwidths of 8-14 kHz were used to elicit ABRs. The current study compared responses among these stimuli. The results demonstrate the reliability of HF-click responses and of tone bursts presented in trains. |
| Databáze: | OpenAIRE |
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