Computational analysis of four human adenovirus type 4 genomes reveals molecular evolution through two interspecies recombination events
| Autor: | James Chodosh, Elizabeth B. Liu, Shoaleh Dehghan, Jason Seto, Michael P. Walsh, David W. Dyer, Donald Seto |
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| Rok vydání: | 2013 |
| Předmět: |
Candidate gene
Gene Transfer Horizontal Pan troglodytes viruses Molecular Sequence Data Sequence alignment Genome Viral Biology Genome Article Adenovirus Infections Human Evolution Molecular Chimpanzee genome project Viral Proteins Zoonosis Molecular evolution Zoonoses Virology Animals Humans Adenovirus Phylogeny Genetics Base Sequence Adenovirus genome Adenoviruses Human Computational Biology virus diseases Sequence Analysis DNA Recombination eye diseases Capsid Viral replication Adenoviruses Simian Sequence Alignment |
| Zdroj: | Virology. 443(2):197-207 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2013.05.014 |
| Popis: | Computational analysis of human adenovirus type 4 (HAdV-E4), a pathogen that is the only HAdV member of species E, provides insights into its zoonotic origin and molecular adaptation. Its genome encodes a domain of the major capsid protein, hexon, from HAdV-B16 recombined into the genome chassis of a simian adenovirus. Genomes of two recent field strains provide a clue to its adaptation to the new host: recombination of a NF-I binding site motif, which is required for efficient viral replication, from another HAdV genome. This motif is absent in the chimpanzee adenoviruses and the HAdV-E4 prototype, but is conserved amongst other HAdVs. This is the first report of an interspecies recombination event for HAdVs, and the first documentation of a lateral partial gene transfer from a chimpanzee AdV. The potential for such recombination events are important when considering chimpanzee adenoviruses as candidate gene delivery vectors for human patients. |
| Databáze: | OpenAIRE |
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