Evaluation of left ventricular functions in patients with pseudoexfoliation syndrome using tissue Doppler echocardiography and its association with plasma BNP levels
| Autor: | Fikret Sen, Idil Göksel, Ayça Yilmaz, Abdullah Cirit, Dilek Cicek Yilmaz, Lülüfer Tamer |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Diastole Pseudoexfoliation syndrome Exfoliation Syndrome Doppler imaging Basal (phylogenetics) Ventricular Dysfunction Left Tissue Doppler echocardiography Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Ejection fraction E/A ratio business.industry Middle Aged medicine.disease Echocardiography Doppler Cross-Sectional Studies cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business human activities Biomarkers |
| Zdroj: | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology. 14(5) |
| ISSN: | 1308-0032 |
| Popis: | Objective Pseudoexfoliation syndrome (PES) is a systemic disorder that involves various visceral organs. In this observational cross-sectional study we aimed to investigate the left ventricular functions in patients with PES by using tissue Doppler imaging and correlations between B-type natriuretic peptide (BNP) levels and cardiac functions. Methods The study enrolled 22 patients with PES (9 male, 41%), aged 57.0 ± 8.8 years, and 23 control subjects (9 male, 39%), aged 52.8 ± 4.9 years. Patients with any cardiovascular disease were excluded. Fasting blood samples were taken and tissue Doppler imaging was performed at the mitral annulus with echocardiographic examination. The independent t and Mann-Whitney U tests were used. Results The Em velocities at the basal septum and lateral annulus were significantly lower in patients with PES showing decreased diastolic functions (7.6 ± 2.0 versus 9.1 ± 1.6 cm/s, p=0.01 and 9.3 ± 3.5 versus 11.5 ± 3.1 cm/s, p=0.04 respectively). While global left ventricular systolic function assessed by ejection fraction was not significantly different between patients with PES and controls, the septum S-wave velocities of PES patients were lower (7.6 ± 1.3 versus 8.5 ± 1.2 cm/s, p=0.03). Total plasma BNP levels were significantly higher in PES patients (129.04 ± 99.38 pg/mL versus 59.64 ± 53.69 pg/mL; p=0.005) and there was a negative correlation between plasma BNP concentration and mitral annulus average Em velocities (r=-0.554, p=0.009). E/Em ratio was also significantly higher in PES patients (7.85 ± 2.01 versus 6.64 ± 1.48, p=0.03). Conclusion In this study we showed decreased left ventricular diastolic functions correlated with plasma BNP levels in PES patients. Although further studies needed, evaluation and follow-up of PES patients in terms of left ventricular functions will be useful. |
| Databáze: | OpenAIRE |
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