Association study between the variants of the human ANP gene and essential hypertension
| Autor: | Mikano Sato, Yoichi Izumi, Katsuo Kanmatsuse, Yukie Takahashi, Yukio Ozawa, Tomohiro Nakayama, Masako Kunimoto, Dolkun Rahmutula, Jiro Uwabo, Masayoshi Soma |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Physiology Essential hypertension Pathogenesis Atrial natriuretic peptide Polymorphism (computer science) Internal medicine Internal Medicine Medicine Humans Risk factor Allele Polymorphism Genetic business.industry Middle Aged medicine.disease Endocrinology Genetic marker Hypertension Cardiology Female Cardiology and Cardiovascular Medicine business Atrial Natriuretic Factor |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 24(3) |
| ISSN: | 0916-9636 |
| Popis: | Variants of atrial natriuretic peptide (ANP) are reported to be more common in blacks with hypertension than in normotensive controls and constitute an independent risk factor for cerebral infarction. The purpose of the present study was to investigate the role of ANP in the pathogenesis of essential hypertension (EH) in the Japanese. We investigated 2 previously reported ANP gene markers, G1837A and T2238C, for their possible associations with EH. A total of 233 individuals with EH and 213 age-matched normotensive (NT) control subjects were studied. The frequencies of the G and A alleles were 0.09 (42/466) and 0.91 (424/466), respectively, for the NT group and 0.11 (47/426) and 0.89 (379/426), respectively, for the EH group. These frequencies did not differ significantly between the two groups. The frequencies of the T and C alleles were 0.024 (11/466) and 0.97 (455/466), respectively, for the NT group and 0.03 (13/426) and 0.97 (413/426), respectively, for the EH group. These frequencies also did not differ significantly between the two groups. Neither G1837A nor the T2238C polymorphism of the ANP gene was associated with EH. Our findings do not support the hypothesis that the G1837A and T2238C polymorphisms of the ANP gene are markers for EH in the Japanese. |
| Databáze: | OpenAIRE |
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